G. Furgi

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Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the so called "β-adrenergic desensitization"). Adrenergic responsiveness is altered with aging and the(More)
The adrenergic system plays a central role in stress signaling and stress is often associated with increased production of ROS. However, ROS overproduction generates oxidative stress, that occurs in response to several stressors. β-adrenergic signaling is markedly attenuated in conditions such as heart failure, with downregulation and desensitization of the(More)
BACKGROUND An active lifestyle is associated with a reduced cardiovascular risk in middle-aged as well as in elderly patients. In the present study, we investigated the association between physical activity habits of elderly participants prior to coronary artery bypass grafting (CABG) and survival free from both all-cause and cardiac death. METHODS AND(More)
Higher neurohormonal activation levels are known markers of severity in heart failure (HF). Aim of the study was to assess the association of Poincarè plot indexes (PPI) of RR time series with plasma norepinephrine (NPE) levels and functional parameters as compared to classical linear indexes of HRV. Ninety-nine HF patients underwent to a 24-hour(More)
Nonlinear analysis of HRV, particularly the fractal dimension and 1/f beta parameters, has been recognized to provide valuable information in the prognostic classification of cardiac patients. The reproducibility of these methods, however, is not known. In this study we addressed these issues in a population of chronic heart failure (CHF) patients. We(More)
Cardiovascular oscillations following spontaneous ventricular premature complexes (VPC) are described by the so-called heart rate turbulence (HRT) onset (TO) and slope (TS). Since HRT is a marker of baroreflex sensitivity, it can be hypothesized to be affected by the preceding VPC sympatovagal balance (pHF). The aim of this study is to investigate the(More)
Quantitative assessment of myocardial blood flow (MBF) by contrast echocardiography (CE) has the potential to become a routine procedure with continued methodologic enhancements. Improved hardware technology, better physical characteristics of the contrast agent (microbubbles), and the development of more advanced algorithms to compute blood flow underlie(More)
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