G. Frank Gerberick

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  • Van Och, De Jong, Van Loveren, R J Dearman, Hilton, Kimber +14 others
  • 2009
INTRODUCTION 4 1. OECD Guidelines for the Testing of Chemicals are periodically reviewed in light of 5 scientific progress, changing regulatory needs, and animal welfare considerations. The first 6 Test Guideline (TG) for the determination of skin sensitisation in the mouse, the Local 7 Lymph Node Assay (LLNA; TG 429) was adopted in 2002 (1). The details of(More)
Allergic contact dermatitis resulting from skin sensitization is a common occupational and environmental health problem. In recent years, the local lymph node assay (LLNA) has emerged as a practical option for assessing the skin sensitization potential of chemicals. In addition to accurate identification of skin sensitizers, the LLNA can also provide a(More)
There is an urgent need to develop data integration and testing strategy frameworks allowing interpretation of results from animal alternative test batteries. To this end, we developed a Bayesian Network Integrated Testing Strategy (BN ITS) with the goal to estimate skin sensitization hazard as a test case of previously developed concepts (Jaworska et al.,(More)
The overall objectives of the IPCS are to establish the scientific basis for assessment of the risk to human health and the environment from exposure to chemicals, through international peer review processes, as a prerequisite for the promotion of chemical safety, and to provide technical assistance in strengthening national capacities for the sound(More)
Three and four state categorical quantitative structure-activity relationship (QSAR) models for skin sensitization have been constructed using data from the murine Local Lymph Node Assay studies. These are the same data we previously used to build two-state (sensitizer, nonsensitizer) QSAR models (Li et al., 2007, Chem. Res. Toxicol. 20, 114-128).(More)
Currently, the only validated methods to identify skin sensitization effects are in vivo models, such as the local lymph node assay (LLNA) and guinea pig studies. There is a tremendous need, in particular due to novel legislation, to develop animal alternatives, for eaxample, quantitative structure-activity relationship (QSAR) models. Here, QSAR models for(More)
The presence of mycotoxins in grains is well documented. Workers in grain handling occupations are commonly exposed to grain dust aerosols. Work in our laboratory has shown that T-2 toxin is highly toxic to rat alveolar macrophages in vitro, causing loss of viability, release of radiolabeled chromium, inhibition of macromolecular synthesis, inhibition of(More)
Alveolar macrophages (AM) from pathogen-free rabbits were unable to release reactive oxygen intermediates (ROI) unless they were conditioned in serum for 24-48 h before triggering with membrane-active agents. The degree of serum conditioning of AM depended upon the concentration of serum used; optimal ROI release was obtained at or above 7.5% fetal bovine(More)
In previous studies we have developed categorical QSAR models for predicting skin-sensitization potency based on 4D-fingerprint (4D-FP) descriptors and in vivo murine local lymph node assay (LLNA) measures. Only 4D-FP derived from the ground state (GMAX) structures of the molecules were used to build the QSAR models. In this study we have generated 4D-FP(More)
105 ACD Allergic contact dermatitis 106 AOO Acetone: olive oil 107 BGIA Berufsgenossenschaftliches Institut fur Arbeitsschutz (German 108 Institute for Occupational Safety and Health) 109 BRD Background Review Document 110 BT Buehler Test 111 CASRN Chemical Abstracts Service Registry Number 112 CCA Chromated copper arsenate 113 CESIO Comite Europeen des(More)
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