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The effect of sinomenine (SIN) on the toll-like receptor (TLR) signal transduction pathway as well as the expression of myeloid differentiation factor 88 (MyD88) and tumor necrosis factor (TNF) receptor-associated factor-6 (TRAF6) was investigated. SIN inhibition of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) proliferation and RA cartilage(More)
OBJECTIVE Malignant peripheral nerve sheath tumours (MPNSTs) are invasive, hard-to-treat, soft tissue sarcomas. In this study, in vitro and in vivo effects of triptolide were investigated using human MPNST cell lines. METHODS Cultured STS-26T and ST88-14 cells were treated with 0-100 ng/ml triptolide (for determination of cell proliferation by(More)
BACKGROUND AND AIMS Treatment with propofol has been found to attenuate oxidative stress injury in rat cardiac cells through the inhibition of programmed cell death. However, the underlying mechanism of this beneficial effect is not clear. Previous studies showed NF-κB (NF-κB) could be activated after oxidative stress in cardiac cells, and p53 up-regulated(More)
Hypoxia-inducible factor-1α (HIF-1α) is considered the main transcriptional regulator of the hypoxia-specific cellular and developmental response. This study was performed to investigate the effect of Shenqin biochemical extract (SQBE) on HIF-1α expression in ultraviolet B (UVB)-irradiated HaCaT cells and the possible action mechanisms of SQBE against(More)
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