G E de Motta

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Anti-HIV-active polysaccharides and polyphenols were isolated from the brown seaweed Fucus vesiculosus by hot H2O extraction of both the intact and the homogenized algae. This was followed by XAD2 chromatography and by sequential precipitation of the non-adsorbed compounds with glacial HOAc and thereafter with EtOH. The precipitate was solubilized, dialyzed(More)
Dibromosceptrin and clathrodin are alkaloid compounds purified from tropical marine sponges of the genus Agelas. Experiments done using the whole cell configuration of the patch clamp technique revealed that these compounds have neurotoxic activity. Both compounds decreased by 27-40% the average maximum amplitudes of pharmacologically isolated inward sodium(More)
Strips of guinea pig ileum lose over 70% of their contractility when bathed in Krebs-Ringer solution containing 0.4-0.9 M formamide (FMD). This effect is not accompanied by an appreciable loss of tissue water and is totally reversed by washing the preparation in normal solution. Frog sartorius muscles also paralyze when immersed in Ringer containing FMD,(More)
Pharmacological studies on the body wall musculature of the sedentary polychaete Sabellastarte magnifica show a potential neurotransmitter role for monoamines and neuropeptides in this organism. All catecholamines induced contraction of longitudinal muscle strips, while serotonin and the neuropeptides FMRFamide and substance P caused a relaxation of both(More)
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