G. E. Mazurkevich

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Purpose. The diffusion equation should be solved for the non-steady-state problem of drug diffusion within a two-dimensional, biphasic stratum corneum membrane having homogeneous lipid and corneocyte phases. Methods. A numerical method was developed for a brick-and-mortar SC-geometry, enabling an explicit solution for time-dependent drug concentration(More)
The diffusion equation has been solved numerically for the non steady-state problem of a two-dimensional, biphasic stratum corneum membrane. A brickand-mortar geometry was used, having variable relative phase permeability, corneocyte arrangement and corneocyte/lipid phase partition coefficient. The dependence of the diffusional pathway and the overall(More)
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