Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

Disposition and metabolic fate of atomoxetine hydrochloride: the role of CYP2D6 in human disposition and metabolism.

• John-Michael Sauer, G Douglas Ponsler, +4 authors Karl A Desante
• Drug metabolism and disposition: the biological…
• 2003

The role of the polymorphic cytochrome p450 2D6 (CYP2D6) in the pharmacokinetics of atomoxetine hydrochloride [(-)-N-methyl-gamma-(2-methylphenoxy)benzenepropanamine hydrochloride; LY139603] has been… (More)

The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2.

• Eric T Williams, Karen O Jones, +6 authors Nagy A. Farid
• Drug metabolism and disposition: the biological…
• 2008

2-Acetoxy-5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (prasugrel) is a novel thienopyridine prodrug with demonstrated inhibition of platelet aggregation and… (More)

Disposition and metabolic fate of atomoxetine hydrochloride: pharmacokinetics, metabolism, and excretion in the Fischer 344 rat and beagle dog.

• Edward L Mattiuz, G Douglas Ponsler, +8 authors John-Michael Sauer
• Drug metabolism and disposition: the biological…
• 2003

These studies were designed to characterize the disposition and metabolism of atomoxetine hydrochloride [(-)-N-methyl-gamma-(2-methylphenoxy)benzenepropanamine hydrochloride; formerly know as… (More)

Inhibition of ATPase activity in rat synaptic plasma membranes by simultaneous exposure to metals.

• Mario Carfagna, G Douglas Ponsler, Barry B. Muhoberac
• Chemico-biological interactions
• 1996

Inhibition of Na+/K+-ATPase and Mg2+-ATPase activities by in vitro exposure to Cd2+, Pb2+ and Mn2+ was investigated in rat brain synaptic plasma membranes (SPMs). Cd2+ and Pb2+ produced a larger… (More)

Cephaloridine-induced renal pathological and biochemical changes in female rabbits and isolated proximal tubules in suspension.

• Georgia Rush, Ruth A. Heim, G Douglas Ponsler, John Engelhardt
• Toxicologic pathology
• 1992

Cephaloridine (Cld) is a nephrotoxic cephalosporin antibiotic. The intracellular biochemical changes that occur leading to Cld-induced nephrotoxicity may involve lipid peroxidation and/or… (More)

Effects of diarylsulfonylurea antitumor agents on the function of mitochondria isolated from rat liver and GC3/c1 cells.

• Georgia Rush, S M Rinzel, George B. Boder, Ruth A. Heim, John E Toth, G Douglas Ponsler
• Biochemical pharmacology
• 1992

Diarylsulfonylureas, such as N-(4-chlorophenyl)aminocarbonyl-2,3-dihydro-1-indene-5-sulfonamide (LY186641, Sulofenur) and N-(4-chlorophenyl)aminocarbonyl-4-methylbenzene sulfonamide (LY181984), have… (More)

Cephaloridine-induced biochemical changes and cytotoxicity in suspensions of rabbit isolated proximal tubules.

• Georgia Rush, G Douglas Ponsler
• Toxicology and applied pharmacology
• 1991

Cephalosporin antibiotics, such as cephaloridine (Cld), are known to be nephrotoxic in vivo and in vitro. In vivo, Cld causes proximal tubule necrosis in rabbits which is preceded by glutathione… (More)

Simultaneous quantification of atomoxetine as well as its primary oxidative and O-glucuronide metabolites in human plasma and urine using liquid chromatography tandem mass spectrometry (LC/MS/MS).

• John H. Mullen, Richard L Shugert, +8 authors John-Michael Sauer
• Journal of pharmaceutical and biomedical analysis
• 2005

A sensitive and selective liquid chromatography tandem mass spectrometry (LC/MS/MS) method for the determination of atomoxetine and its metabolites (4-hydroxyatomoxetine, N-des-methylatomoxetine, and… (More)

Relationship between atomoxetine plasma concentration, treatment response and tolerability in attention-deficit/hyperactivity disorder and comorbid oppositional defiant disorder

• Philip Hazell, Katja Becker, +8 authors Ralf Dittmann
• Attention deficit and hyperactivity disorders
• 2009

The purpose of this study was to examine whether atomoxetine plasma concentration predicts attention-deficit/hyperactivity disorder (ADHD) or oppositional defiant disorder (ODD) response. This… (More)

Biochemical mechanisms of cephaloridine nephrotoxicity in suspensions of isolated rabbit proximal tubules.

• Georgia Rush, G Douglas Ponsler
• Toxicology letters
• 1990

• ‹
• 1
• ›