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Deregulated Notch signaling is associated with T-cell Acute Lymphoblastic Leukemia (T-ALL) development and progression. Increasing evidence reveals that Notch pathway has an important role in the invasion ability of tumor cells, including leukemia, although the underlying molecular mechanisms remain mostly unclear. Here, we show that Notch3 is a novel(More)
It is accepted that studies evaluating histamine-induced wheal and flare reactions in the skin represent a simple and reliable method for demonstrating pharmacodynamic activity and pharmacokinetics of the H1-receptor antagonists. In this study, the effects of single oral doses of acrivastine (8 mg), loratadine (10 mg) and cetirizine (10 mg) on the(More)
The standard sequencing gel system using Tris/Borate/EDTA does not allow separation of DNA fragments >300nts. albeit with the use of long gels and/or longer running time. We have used the discontinuous buffer system first introduced by Allen (1): it uses Tris-sulphate/leading anion as running gel buffer and Tris-borate/trailing anion as tank buffer. We have(More)
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