G. D. Shorten

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A method is presented for the automatic determination of a patient's level of sedation from the EEG. Six bipolar channels of EEG recorded from 12 adult patients sedated with low-dose propofol (2, 6-disopropylphenol) were used to develop a linear discriminant based system for depth of sedation monitoring using a number of quantitative EEG measures. A cross(More)
SUMMARY In this prospective observational study we examined the potential of the spectral entropy measures 'state' and 'response' entropy (Entropy monitor), as measures of sleep depth in 12 healthy adult subjects. Both median state and response entropy values varied significantly with sleep stage (p = 0.017 and p = 0.014 respectively; ANOVA). Median state(More)
Edrophonium and neostigmine are anticholinesterase drugs used commonly to antagonize competitive neuromuscular block. Although it has a faster onset of action than neostigmine, edrophonium is unreliable when used to antagonize deep neuromuscular block. We have compared the antagonist characteristics of these two drugs when used to antagonize a moderate(More)
This study documents the response to atracurium (75 micrograms.kg-1) administered 30 min after a pancuronium- or tubocurarine-induced neuromuscular block has been reversed with either neostigmine (50 micrograms.kg-1) or edrophonium (0.5 mg.kg-1). Twenty-one ASA 1 or 2 patients were studied, of whom 11 received neostigmine and 10 edrophonium. The degree of(More)
The risk of mistaking a dystonic reaction following trifluoperazine for tetanus is well recognised' 2 In 1979, Stoddart3 reported six cases of pseudo-tetanus, "a syndrome which is produced by a variety of non-clostridial factors". Trifluoperazine was implicated in one of these cases. We report a similar instance in which circumstantial evidence supported(More)
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