G. D. R. Zon

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Papillomaviruses induce benign proliferative lesions, such as genital warts, in humans. The E2 gene product is thought to play a major role in the regulation of viral transcription and DNA replication and may represent a rational target for an antisense oligonucleotide drug action. Phosphorothioate oligonucleotides complementary to E2 mRNAs were synthesized(More)
Because of the importance of monocytes/macrophages (M/M) as an in vivo reservoir of human immunodeficiency virus (HIV), a study was done to investigate whether viral replication in chronically infected macrophages (HIV M/M) could be inhibited by various drugs, including U-75875, an inhibitor of HIV protease. HIV replication in M/M and in chronically(More)
  • G Zon
  • 1990
The use of antisense oligonucleotides for controlling genetic expression has recently received widespread attention, especially as a new class of potential chemotherapeutic agents. This coupled with the urgency of developing new effective therapies for acquired immunodeficiency syndrome (AIDS) has led to various antisense studies dealing with human(More)
  • Erik David Fosshage, Erik D. Fosshage, +15 authors Tom Wubbels
  • 2016
This is to certify that the thesis/dissertation prepared By Entitled For the degree of Is approved by the final examining committee: Chair To the best of my knowledge and as understood by the student in the Research Integrity and Copyright Disclaimer (Graduate School Form 20), this thesis/dissertation adheres to the provisions of Purdue University's "(More)
This paper describes the results of the two assessments performed to evaluate the impact of increasing levels of automation (LoA) on Human Factors aspects and the impact on their responsibilities and interactions. This activity has been developed within the "Assessment of Degree of Automation on Human Roles" (ADAHR) project inside the framework of SESAR(More)
This paper presents the overall learning process that evolved during the MASCA project (MAnaging System Change in Aviation—EU FP7 funded project (2010–2013), specifically focusing on the one of the key elements of the overall learning approach, the development of a serious game (SKYBOARD) and the role the game played in supporting the implementation of(More)
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