G. D. Guthrie

Learn More
OBJECT Glioblastoma multiforme (GBM) is the most common astrocytic brain tumor and carries a dire prognosis. Despite current therapeutic options--surgery, radiotherapy, and chemotherapy--survival varies from 11.3 to 14.6 months. A group of drugs known as histone deacetylase inhibitors (HDIs) has demonstrated a potentially beneficial role in cancer(More)
It has been recognized since at least as early as the mid-1500s that inhaled minerals (i.e., inorganic particles) can pose a risk. Extensive research has focused on the biological mechanisms responsible for asbestos- and silica-induced diseases, but much less attention has been paid to the mineralogical properties and geochemical mechanisms that might(More)
Reduced-order modeling is a promising approach, as many phenomena can be described by a few dominant modes/mechanisms. The goal of this paper is to assess the utility of Reduced-Order Models (ROMs) developed from three-dimensional physics-based models for predicting transient thermal power output for an enhanced geothermal reservoir while explicitly(More)
Crystal defects and chemical reactions occurring at scales beyond the resolution of light microscopes have major effects on the chemical and physical properties of rocks and minerals. High-resolution imaging, diffraction, and chemical analysis in the transmission electron microscope have become important methods for exploring mineral defect structures and(More)
  • 1