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As currently implemented, magnetic resonance imaging (MRI) relies on the protons of water molecules in tissue to provide the NMR signal. Protons are, however, notoriously difficult to image in some biological environments of interest, notably the lungs and lipid bilayer membranes such as those in the brain. Here we show that 129Xe gas can be used for(More)
Two healthy volunteers who had inhaled approximately 0.75 L of laser-polarized helium-3 gas underwent magnetic resonance imaging at 1.5 T with fast gradient-echo pulse sequences and small flip angles ( < 10 degrees). Thick-section (20 mm) coronal images, time-course data (30 images collected every 1.8 seconds), and thin-section (6 mm) images were acquired.(More)
We propose to measure the parity-violating electroweak asymmetry A P V in the deep-inelastic scattering of polarized electrons (PVDIS) to high precision in order to search for physics beyond the Standard Model in lepton-quark neutral current interactions. Presently, the atomic parity-violation measurement in 133 Cs provides important limits on such new(More)
The upgraded 11 GeV CEBAF polarized electron beam presents a compelling opportunity to measure a weak neutral current amplitude to unprecedented precision at Q 2 M 2 Z. The result would yield a precise measurement of the weak mixing angle sin 2 θ W , a fundamental parameter of the electroweak theory. The experimental goal of δ(sin 2 θ W) ∼ 0.1%, matching(More)
Magnetic resonance images of the lungs of a guinea pig have been produced using hyperpolarized helium as the source of the MR signal. The resulting images are not yet sufficiently optimized to reveal fine structural detail within the lung, but the spectacular signal from this normally signal-deficient organ system offers great promise for eventual in vivo(More)
The magnetization in hyperpolarized gas (HP) MRI is generated by laser polarization that is independent of the magnet and imaging process. As a consequence, there is no equilibrium magnetization during the image acquisition. The competing processes of gas inflow and depolarization of the spins lead to large changes in signal as one samples k-space. A model(More)
Using a new method of xenon laser-polarization that permits the generation of liter quantities of hyperpolarized 129Xe gas, the first 129Xe imaging results from the human chest and the first 129Xe spectroscopy results from the human chest and head have been obtained. With polarization levels of approximately 2%, cross-sectional images of the lung gas-spaces(More)
We report on extensive experimental measurements of the key rates that determine the efficiency for polarizing the nuclei of 3 He by spin exchange with optically pumped Rb vapor. In agreement with recent theoretical predictions, we find a strong temperature dependence of the electron-spin loss rates due to 3 HeRb collisions. We also find that the maximum(More)
The instrumentation in Hall A at the Thomas Jefferson National Accelerator Facility was designed to study electro-and photo-induced reactions at very high luminosity and good momentum and angular resolution for at least one of the reaction products. The central components of Hall A are two identical high resolution spectrometers, which allow the vertical(More)