Learn More
A massive degeneration of dopamine-containing neurons in the substantia nigra (SN) in the midbrain is characteristic of Parkinson's disease. Inflammation in the brain has long been speculated to play a role in the pathogenesis of this neurological disorder. Recently, we reported that treatment of primary rat mesencephalic mixed neuron-glia cultures with(More)
OBJECTIVE To determine how memory-encoding tasks elicit functional perfusion change in subjects with amnestic mild cognitive impairment (aMCI). METHODS Twelve subjects with aMCI and 14 age-matched cognitively normal (CN) subjects were recruited for this study. Arterial spin-labeling perfusion MRI (ASL-MRI) was employed to measure regional cerebral blood(More)
Previous studies have shown that dopamine (DA) is involved in electroacupuncture analgesia (EAA). L-tetrahydropalmatine (l-THP), a DA receptor antagonist was proved to potentiate EAA in both laboratory research and clinical practice. In the present study SK&F-38393 and quinpirole (Qui), selective agonists of D1 or D2 receptors respectively were injected(More)
Homoploid hybrid speciation is the formation of a new hybrid species without change in chromosome number. So far, there has been a lack of direct molecular evidence for hybridization generating novel traits directly involved in animal speciation. Heliconius butterflies exhibit bright aposematic color patterns that also act as cues in assortative mating.(More)
In this paper, we aim to study the cognitive integration of asynchronous natural or non-natural auditory and visual information in videos of real-world events. Videos with asynchronous semantically consistent or inconsistent natural sound or speech were used as stimuli in order to compare the difference and similarity between multisensory integrations of(More)
In this paper, we aimed to study the semantic association of ecologically unrelated synchronous audio-visual information in cognitive integration. A moving particle, which speed varied, was taken as a visual stimulus, while a simple tone, which frequency varied, was used as an auditory stimulus, both were synchronously presented to subjects in the form of a(More)
The wing patterns of butterflies and moths (Lepidoptera) are diverse and striking examples of evolutionary diversification by natural selection. Lepidopteran wing colour patterns are a key innovation, consisting of arrays of coloured scales. We still lack a general understanding of how these patterns are controlled and whether this control shows any(More)
BACKGROUND Protein-coding change is one possible genetic mechanism underlying the evolution of adaptive wing colour pattern variation in Heliconius butterflies. Here we determine whether 38 putative genes within two major Heliconius patterning loci, HmYb and HmB, show evidence of positive selection. Ratios of nonsynonymous to synonymous nucleotide changes(More)
The present study was undertaken to explore central mechanisms underlying the analgesic effect of melatonin. Push-pull perfusion technique and radioimmunoassay were used to observe the changes in the contents of beta-endorphin (beta-Ep) and leucine-enkephalin (L-EK) in the perfusate from the rat periaqueductal gray (PAG) after administration of melatonin.(More)
Dopaminergic neurotoxicities of 6-hydroxydopamine (6-OHDA) and the lipopolysaccharide (LPS) were compared in rat mesencephalic cultures plated on poly-L-lysine or on glial monolayers. In the neuron-enriched cultures plated on polylysine, 6-OHDA killed 89% of the tyrosine hydroxylase (TH)-immunopositive neurons, but LPS was not neurotoxic. Conversely, in(More)