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AIM: To evaluate whether fat distribution plays a role in determining serum leptin concentrations.PATIENTS AND METHODS: One-hundred and forty-seven obese patients, 77 males and 70 females, aged 45.1±13.2 y (mean±s.d.; range 21–73 y), with body mass index (BMI) ranging from 30 to 55 kg/m2 (mean 42.3±5.9). Ultrasound assessment of the thickness of(More)
OBJECTIVE: To study clinical, anthropometric and metabolic determinants of serum leptin concentrations in a series of patients with a wide range of obesity.SUBJECTS: 400 patients, 116 males and 284 females, aged 44±12.3 years with body mass index (BMI) ranging from 31 to 82 kg/m2 (mean 41.4±7.1).MEASUREMENTS: Energy intake by 7-day recall, resting energy(More)
Objective:Studies on the prevalence of metabolic syndrome (MS) in European obese children using child-based criteria are scanty. Moreover, it is unknown if nontraditional cardiovascular disease (CVD) risk factors are associated with the MS at this early age in these subjects.Design and subjects:We studied the prevalence of the MS in 588 Caucasian obese(More)
OBJECTIVE To evaluate whether subclinical hypothyroidism (SH) affects resting energy expenditure (REE) as well as body composition, lipid profile, and serum leptin in obese patients. RESEARCH METHODS AND PROCEDURES A total of 108 obese patients with SH defined as normal free thyroxine levels and thyroid-stimulating hormone (TSH) values of > 4.38 microU/ml(More)
AIM In obese patients, the diet-induced weight loss markedly improves glucose tolerance with an increase in insulin sensitivity and a partial reduction of insulin secretion. The association with metformin treatment might potentiate the effect of diet alone. METHODS From patients admitted to our Nutritional Division for diet programme, we selected obese,(More)
  • G C Viberti
  • International journal of clinical practice
  • 2003
Rosiglitazone, a potent member of the thiazolidinedione class of oral antidiabetic agents, reduces hyperglycaemia by improving insulin sensitivity--an important underlying factor in the development of both type 2 diabetes and its related cardiovascular complications. Rosiglitazone has now been available in clinical practice for more than three years, so(More)
UICKI is an index of insulin sensitivity based on the determination of glucose and insulin concentrations in the postabsorptive state [1]. It has been shown to be well correlated with insulin sensitivity across the entire spectum of glucose tolerance, but its performance is less satisfactory in normal subjects [1]. To overcome this drawback, QUICKI has been(More)
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