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Neurons from peripheral and central nervous tissue as well as from established cell lines respond to low concentrations of laminin with rapid extension of axon-like processes. Two sites on laminin have been identified which stimulate neurite outgrowth, the major site residing at the end of the long arm of laminin. Recently laminin has been cloned and(More)
The process of neurite extension is complex and mechanisms involved probably vary depending on the local microenvironment (tissue site, extracellular matrix, neighboring cells, humoral factors, and developmental stage) of the developing or repairing neuron. Laminin contains at least one and perhaps more sites capable of stimulating process formation in a(More)
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