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We have synthesized a new and stable MR contrast agent, SPIO-mPEG-cRGD, that exhibits superior binding to the biologic target αvβ3 integrins. Selective targeting of αvβ3 integrins was achieved by conjugating cyclic RGD peptides to the superparamagnetic iron oxide nanoparticles (SPIO) surface, while poly(ethylene glycol) (PEG) were used for nonimmunogenic,(More)
  • G-C. Liu
  • Zhongguo yi xue ke xue yuan xue bao. Acta…
  • 1991
Genomic DNA PvuII fragments containing the 3'HVR from 52 unrelated Chinese of Han nationality varied between 1.7 kb and 10.0 kb and showed high polymorphism. The genomic DNA PvuII fragments from five families with adult polycystic kidney disease (APKD) were analyzed using the alpha-globin gene 3' HVR (hypervariable region) as probe. The results showed a(More)
  • G-C. Liu
  • Zhongguo yi xue ke xue yuan xue bao. Acta…
  • 1992
In this paper, DNA probe labeling by the randomly primed incorporation of digoxigenin-dUTP is reported. The sensitivity of color reaction and hybridization were 32 fg and 200 fg, respectively, and both were specific for the target. Single-copy and multi-copy gene fragments among 2 micrograms human genomic DNA were detected by beta IVS II, Fr 3-42 and 3'HVR(More)
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