G. B. Hutchinson

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MOTIVATION To develop an algorithm utilizing differential hexamer frequency analysis to discriminate promoter from non-promoter regions in vertebrate DNA sequence, without relying upon an extensive database of known transcriptional elements. RESULTS By determining hexamer frequencies derived from known promoter regions, coding regions and non-coding(More)
Alu repetitive elements represent the most common short interspersed elements (SINEs) found in primates, with an estimated 500,000 members in the haploid human genome. Considerable evidence has accumulated that these elements have dispersed in the genome by active transcription followed by retroposition, and that this process is ongoing. Sequence variation(More)
As part of the search for the Huntington disease (HD) gene we have cloned and sequenced 34 kb of genomic DNA containing the full-length gene for the beta-subunit of the human cGMP phosphodiesterase (beta-cGMP PDE). This gene is localized to 4p16.3 about 700 kb proximal to the 4p telomere and represents the most telomeric gene characterized on 4p to date. We(More)
Huntington's disease (HD) is a late-onset autosomal dominant neuropsychiatric disorder presenting in mid-adult life with personality disturbance and involuntary movements, cognitive and affective disturbance, and inexorable progression to death. The underlying genetic defect has been mapped to chromosomal band 4p16.3 (refs 2, 3). Analysis of specific(More)
Course Description This course is an introduction to the history, theory, and practice of the representation of archival materials. This course examines arrangement principles and descriptive standards for intellectual access to archival materials. Students study different types of surrogates, including finding aids, MARC, and EAD, and various archival(More)
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