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The action of non-competitive glutamate receptor antagonists on the effects of sleep deprivation has been studied on Krushinskii-Molodkina rats having an inherited predisposition to audiogenic seizures and Wistar rats deprived to this respond. Two types of glutamate receptor open channels blockers were used: the selective blockers of NMDA-receptors(More)
Simultaneous recording of the EEG activity of superficial cortical and deep (caudate nucleus, dorsal hippocampus, anterior hypothalamus) brain parts has been performed for the first time after a 2-h swinging of frequency of 0.2 Hz in Wistar rats of juvenile age. Swinging was produced on a 4-bar parallel swing. Using a Neuron-Spectr electroencephalograph and(More)
Influence of aluminum little concentrations on rats CNS was carry out in chronic experiments. The increase of beta1- and beta2-power density in visual and sensomotor cortex, hippocampus and n. caudatus EEG during slow wave sleep has been shown after single intramuscular injection of AlCl3 in doses 50, 5 and 3 mg/kg. Such effect was not observed after single(More)
The aim of our study was to investigate the role of dopaminergic system in telencephalic and diencephalic brain regions of vertebrates in sleep-wakefulness cycle. The level of thyrosine-hydroxylase--the main enzyme in dopamine synthesis--was measured in striatum, zona inserta supraoptic and arcuate nuclea of hypothalamus in fish (Acipenceridae) and in(More)
Krushinskii-Molodkina strain rats have an inherited predisposition to audiogenic convulsions and are used as a natural animal model in the anticonvulsive drugs studies. We have investigated whether changes in the glutamatergic synaptic transmission are involved in the mechanism of audiogenic convulsions and functional organization of sleep-waking cycle(More)
Six hours sleep deprivation experiments were carried out on rats after threefold injection of D1 dopamine receptor antagonist SCH 39 166. Immunohistochemical study of striatum revealed the increase in D1 and D2 dopamine receptor and glutamate immunoreactive material during the sleep deprivation and 2 h of postdeprivation period. The level of AMPA glutamate(More)
Certain shifts in activities of some cerebral structures were found to depend on the stage of the sleep-wakefulness cycle and the type of the CNS pathology in Wistar rats with genetic predisposition to catalepsy or audiogenic seizures. The findings suggest participation of the caudate nucleus in regulation of the cycle through modulation of thalamo-cortical(More)