G A Monti Graziadei

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Rats with one olfactory bulb removed when neonates and the second bulb removed when adults were tested on tone-light discrimination and odor detection tasks. On the neonatally operated side reconstituted olfactory receptor cell axons penetrated the frontal neocortex or portions of the anterior olfactory nucleus, and formed glomerular-like structures. On the(More)
Unilateral olfactory nerve section was performed in the mouse. Three biochemical markers of the olfactory chemoreceptor neurons: carnosine, carnosine synthetase activity and the olfactory marker protein, were measured in the olfactory bulb and epithelium. Parallel observations were made by light microscopy as well as at the ultrastructural level. The(More)
Following total, unilateral bulbectomy in neonatal mice, the olfactory sensory axons regrow from a reconstituted population of sensory neurons, cross the lamina cribrosa, and invade the spared forebrain that has leaned forward toward the anteroventral wall of the cranial cavity. The sensory axons invade several regions of the spared forebrain, at times(More)
The morphological study presented here provides a general description of the elements of the olfactory epithelium in the mud puppy and tiger salamander,, and gives evidence about their dynamic activity and interrelationships. There are morphological indications of local bursts of reduplication and a continual line of differentiation of receptor cells from(More)
Section of the fila olfactoria in squirrel monkey, a non-human primate, induces rapid degeneration of the sensory axon terminals in the olfactory bulb glomeruli. A population of axons, from newly formed sensory neurons in the olfactory neuroepithelium, regrow, passes the lamina cribrosa and, upon reaching the olfactory bulb, reinnervates the glomeruli. A(More)
Total unilateral bulbectomy induces degeneration of the mature olfactory neurons and disappearance of the olfactory marker protein from the primary sensory pathway. Owing to the presence of a neurogenetic matrix in the neuroepithelium, reconstitution of a new population of neuronal elements occurs. In this experiment, connections of the regrown olfactory(More)
Axotomy at the level of the lamina cribrosa in rat induces rapid degeneration of the olfactory sensory axons in the bulb. The phenomenon, which is limited to the layer of olfactory fibres and to the glomeruli of the bulb, can be observed as early as 15-24 h after surgery, and peaks at 3-4 days. The glomeruli located in the rostro-ventral portion of the bulb(More)