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Standard autoradiographic tracing methods which employed intracortical injections of 3H-leucine were used to describe the time course of development in those components of the corticopontine system which originate in sensorimotor (SM) or visual (VIS) cortices. These studies were performed using male or female pigmented rats ranging in age from 1 to 24 days(More)
Orthograde axonal transport tracing methods were used to describe the projections to the basilar pontine nuclei (BPN) which arise within the face representation of motor or somatosensory cerebral cortex. Injections centered in motor face (MF) cortex resulted in the labeling of several corticopontine terminal fields which exhibit a rostrocaudal columnar(More)
STUDY OBJECTIVES In this study, we test the hypothesis that when REM-state activation (which impinges upon all lateral geniculate nucleus laminae irrespective of stimulating eye) is deprived, the monocular segment (MS) that is cut off from visual input and also deprived of REM-state activation will exhibit smaller cells, owing to the loss of extrinsic as(More)
Previous reports from this laboratory and elsewhere have provided evidence that the locus coeruleus (LC) and dorsal raphe (DR) nuclei are topographically organized with respect to their efferent targets. Whereas most of these previous studies have focused on relationships between these monoamine-containing brainstem nuclei and cerebral cortex, basal(More)
The abundance of rapid eye movement (REM) sleep in the neonatal mammal and its subsequent decline in the course of development, as well as the dramatic and widespread enhancement of CNS activity during REM sleep, led us to propose that this state plays a functional role in the normative physiological and structural maturation of the brain [54]. When, after(More)
The present study was conducted to examine the spatial organization of dorsal (DR) and median (MR) raphe neurons that project to rostrocaudally aligned areas of the rat cerebral cortex. An additional goal was to determine if individual DR cells that send efferents to forelimb sensorimotor or visual regions of the neocortex also send axon collaterals to(More)
The retrograde transport of the conjugate wheat germ agglutinin-horseradish peroxidase (WGA-HRP) was used in the rat to identify the cell bodies of origin for all subcortical projections to the basilar pontine nuclei (BPN). A parapharyngeal surgical approach was used to allow the injection micropipette to enter the BPN from the ventral aspect of the(More)