G A Grigor'ian

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  • G A Grigor'ian
  • 2012
A review. Current models of aggressive behavior in animals are described. They include aggression due to social isolation; territorial aggression in pair "intruder-resident"; aggression elicited by direct electrical stimulation of the brain; maternal aggression; learned aggression and genetic models. The models are analyzed comparatively and their(More)
  • G A Grigor'ian
  • 2004
In this paper some new methods for studying of general cognitive ability, g, and their experimental testing on mice are proposed. Instead of techniques based on learning processes with application of many trials and gradual elaboration of a habit, the proposed methods allow to assess behaviour by using only one or a few trials and to compare such behaviour(More)
Different types of individual behavior are described in terms of under- or overestimation of reinforcement characteristics by the brain under conditions of uncertainty of reinforcement presentation. The following important biological characteristics of a subject are discussed, such as anxiety, fear, neuroticism, impulsiveness, self-control and psychoticism(More)
In this paper the problem of "impulsive" and "self-control" behaviour in animals and the experimental models for their assessment are discussed. It is pointed out that a widely accepted model for assessment of impulsive behaviour in animals predominantly measures their ongoing properties of impulsivity/self-control independently on belonging them to the(More)
In this paper we have attempted to relate and explain the activity of the brain different integrative levels, which ends up with occurrence of a goal-directed behaviour and reinforcement. Two main mechanisms of responding to subjects and events of external environment, as rapid executive reactions and slow motivational-emotional states, have been marked(More)
Here we review modern data on appearance and maintenance of depression at different levels of the body. We discuss a role of impairments of emotional and motivation mechanisms of adaptive behavior in genesis of depression. We demonstate an interaction of stress response and neuroinflammatory processes in pathogenesis of depression and analyze the effects of(More)
  • G A Grigor'ian
  • 2011
In the current paper a role of the serotinergic system in organization of impulsive behaviour in animals was considered. The results of influence of antagonists and agonists of the different types and subtypes of 5-HT receptors (1A, B; 2A, B, C; 7) and the effects of the dorsal raphe nuclei lesions on characteristics of impulsivity related with a motor(More)
In this paper a structure of a microdialytic cannula inserted into brain areas just before a microdialysis is described. The cannula used allowed to find out a correspondence of behavioral and biochemical changes in C57BL/6 mice at various time intervals after a single dose administration (20 mg/kg) of the neurotoxin,(More)
The influence of enriched environment on the long-term posttetanic potentiation of hippocampal evoked potentials is discussed. The attention is focused on the effects of novelty, aging and the influence of enriched environment on synaptic processes in hippocampal neurons in transgenic animals. The evidence that the exposure to the enrichment of the(More)
It was shown that the two-way interaction between neurons of the frontal cortex and n. accumbens progressively increases, whereas their regularity simultaneously decreases with the rise in impulsiveness and drop in self-control in behavior. In case of the long-latency instrumental reactions, a control of the frontal cortex neurons by neurons of the n.(More)