G A Brunekreef

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PURPOSE Extralenticular expression of alpha- and beta-crystallin genes has been demonstrated in mammals and expression of gamma-crystallin genes has been shown in Xenopus laevis. To determine a possible correlation between lens determination and crystallin gene expression, the site of expression of (a member of) the alpha-, beta-, and gamma-crystallin gene(More)
In duck, the housekeeping enzyme lactate dehydrogenase B (LDH-B) and the lens structural protein epsilon-crystallin are encoded by the same single copy gene. Transcription of the gene is initiated from two closely spaced start sites, at -28 and +1. The usage of the downstream site is greatly enhanced in lens. Deletion mapping of the promoter shows that the(More)
The pattern of factors binding to either the Sp1-consensus sequence or to the octamer sequence during in vitro rat lens fibre cell differentiation has been examined by electrophoretic mobility shift assays. With the Sp1-consensus sequence as probe, two major and four minor bands were seen. Three bands were present at all stages of differentiation, two are(More)
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