Günther W. Pfeifer

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The GroEL/GroES chaperonin system mediates the folding of a range of newly synthesized polypeptides in the bacterial cytosol. Using a rapid biotin-streptavidin-based inhibition of chaperonin function, we show that the cage formed by GroEL and its cofactor GroES can have a dual role in promoting folding. First, enclosure of nonnative protein in the(More)
In the choice of anaesthetics and techniques the danger of a possible progressive increase of intracranial pressure (ICP) should be considered. Therefore the influence of intravenous anaesthetic agents on mean arterial pressure, ICP, and cerebral perfusion pressure (CPP) in patients with primarily increased ICP was observed under standard conditions for(More)
AIM Unfavourable facial growth in patients with cleft lip, alveolus, and palate may occur during puberty. Usually this development is not predictable in a young patient. The aim of the present study was to find an individual growth prediction at an early age that would allow us to decide whether later orthognathic surgery should be included in the treatment(More)
Even today antibiotic therapy of postoperative or posttraumatic meningitis remains a problem. In patients in a neurosurgical intensive care unit, nosocomial microorganisms with high resistance are mainly found. There are no antibiotics available which have simultaneously a good efficacy on the higher resistant nosocomial microorganisms and a good(More)
Haemodynamic studies were carried out in 12 patients who had sustained severe head injury. Radial artery pressure (AP), pulmonary artery pressure (PAP), central venous pressure (CVP), and pulmonary wedge pressure (PAWP) were directly measured. Heart rate was monitored from the ECG, and cardiac output (CO) was measured intermittently by the thermodilution(More)
For the reconstruction of nasal defects, paramedian forehead flaps with a small pedicel are used. The nutrition of these flaps depends on the presence of an arterial blood vessel in the pedicel. In constructing the flap it is absolutely necessary to know the position and the course of the vessles in the forehead. The branches of the ophthalmic artery -(More)
The Hamburg classification of craniofacial anomalies is introduced; it was first published by Pfeifer in 1967 and has been used in our hospital ever since. This morphogenetic classification is based on embryological data and divides the head into three major regions. Subclassification in the individual regions is done according to anatomical details. This(More)
In 8 patients having primarily an increased ICP, the effects of etomidate on ICP, arterial pressure and cerebral perfusion pressure (CPP) were studied by comparison with thiopentone. The patients received no premedication or basic anaesthesia and relaxation was obtained using pancuronium bromide. Blood gas analysis was performed at regular intervals to(More)