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OBJECTIVE To investigate the pharmacokinetics and safety of a daily infusion of 500 mL of hydroxyethyl starch (HES) [130/0.4] 10% solution on 10 consecutive days. STUDY DESIGN AND PARTICIPANTS An open, one-way, multiple-dose study was performed in 12 healthy male volunteers. Daily infusions over 30 minutes of 500 mL of HES (130/0.4) 10% solution were(More)
OBJECTIVE To assess the pharmacokinetics of anti-D IgG in pregnant Rhesus D-negative women after intramuscular and intravenous administration of 300 microg of Rhophylac. DESIGN An open, randomised, multicentre study. SETTING Seven gynaecological practices in Germany. SAMPLE Fourteen RhD-negative pregnant women at risk of becoming Rhesus D immunised(More)
Forty-one patients underwent bone marrow transplantation (BMT) for treatment of severe aplastic anemia or hematologic malignancies. Hemopoietic reconstitution after BMT was monitored by peripheral blood counts, counts of bone marrow cellularity, and clonal assays for hemopoietic progenitors (CFUc, CFUe, and BFUe), along with bone marrow morphology. The(More)
Guidelines for the performance and analysis of bioequivalence studies are not very specific. The advantages and disadvantages of the following methods and tests are discussed: analysis of variance by summation or by use of general linear models, nonparametric procedures, aposteriori probabilities and tests on the normality of residuals and on the(More)
The granulocyte cell renewal system of the dog is represented by a mathematical model consisting of the following compartments: The pool of pluripotential stem cells, the committed stem cell pool, divided into a blood and a bone marrow compartment, the proliferation pool, the maturation pool, the reserve pool and the blood pool of functional granulocytes.(More)
OBJECTIVES To characterize the safety, tolerability, pharmacokinetics (PK) and dose proportionality of mipomersen after single subcutaneous (SC) administration to Japanese healthy subjects; and to compare the PK profiles of Japanese and Western subjects. METHODS 20 healthy first-generation Japanese male subjects were enrolled into one of three treatment(More)
INTRODUCTION Sialendoscopy and sialo-MRI enable diagnosis of salivary gland obstructive pathologies, such as lithiasis, stenosis and dilatations. Therefore, a classification of these pathologies is needed, allowing large series comparisons, for better diagnosis and treatment of salivary pathologies. MATERIAL AND METHODS With help from people from the(More)
Moxonidine is an imidazoline-type antihypertensive agent, an agonist at central presynaptic R2-adrenoceptors and imidazole receptors [1, 2]. It reduces the blood pressure in hypertensive patients and has few reported adverse effects [3], Its systemic availability, pharmacokinetics after single and multiple dosing, and the effect of renal impairment on its(More)
Some 200 billion red cells, 120 billion granulocytes, 20 billion lymphocytes and 150 billion platelets are lost from the blood stream every day by migration and/or removal (Fliedner et ai., 1976). For each cell lost, another will enter the blood stream from extravascular storage and/or production sites to maintain a steady state equilibrium. Under these(More)