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The present paper summarizes recommendations on transcranial sonography (TCS) application in neurodegenerative diseases, resulting from a consensus meeting of the European Society of Neurosonology and Cerebral Hemodynamics. TCS of distinct infra- and supratentorial brain structures detects characteristic changes in several movement disorders, such as… (More)
BACKGROUND AND PURPOSE Transcranial color-coded duplex sonography (TCCS) enables visualization of the intracranial parenchymal structures and measurement of blood flow velocity in the basal cerebral arteries. The present study aims to evaluate prospectively the clinical usefulness of TCCS in patients with acute stroke. METHODS Eighty-four consecutive… (More)
The general toxic effects of coumarin, as well as coumarin hepatotoxicity were found to be less in DBA/2J mice than in CH3/HeJ mice. These results are discussed in the context of a strain-specific coumarin metabolism and indicate the need for suitable animal models to assess the toxicity of a given substance in man.
BACKGROUND Stroke patients should be cared for in accordance with evidence-based guidelines. The extent of implementation of guidelines for the acute care of stroke patients in Germany has been unclear to date. METHODS The regional quality assurance projects that cooperate in the framework of the German Stroke Registers Study Group (Arbeitsgemeinschaft… (More)
BACKGROUND AND PURPOSE Color-coded perfusion maps can be calculated from ultrasound harmonic gray-scale imaging data after ultrasound contrast agent bolus injection to analyze brain tissue perfusion. First reports indicate that this method can display cerebral perfusion deficits in acute ischemic stroke. We performed a prospective patient study to evaluate… (More)
Initial reports indicate that cerebral perfusion deficits in acute ischemic stroke might be detectable by means of transcranial harmonic imaging after an ultrasound contrast agent (UCA) bolus injection. Twenty-four patients with acute middle cerebral artery (MCA) infarction were investigated twice with perfusion harmonic imaging (PHI) after Levovist… (More)
Perfusion harmonic imaging of the brain is a new ultrasound technique for assessing cerebral perfusion. In a patient with acute middle cerebral artery infarction, this method detected a cerebral perfusion deficit corresponding to the area of delayed perfusion as displayed by perfusion magnetic resonance imaging.
BACKGROUND AND PURPOSE Initial reports indicate that transcranial harmonic imaging after ultrasound contrast agent bolus injection (BHI) can detect cerebral perfusion deficits in acute ischemic stroke. We evaluated parametric images of the bolus washout kinetics. METHODS Twenty-three patients with acute internal carotid artery infarction were investigated… (More)