Günter Graf

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Thrombopoietin (TPO) is a major regulator of megakaryocytopoiesis both in vivo and in vitro. TPO initiates its biological effects by binding to the c-MPL receptor, which is a member of the hematopoietin receptor superfamily. To define the regulation of the MPL receptor, six continuous human leukemia cell lines with megakaryocytic properties were treated(More)
Thrombopoietin (TPO) is a recently characterized growth and differentiation factor for megakaryocytes and platelets exerting its effects via the receptor MPL. We examined the expression of MPR on the cell surface of a panel of 43 myelomonocytic, erythroid and megakaryocytic leukemia cell lines and 21 primary acute myeloid leukemia (AML) cases by flow(More)
Thrombopoietin (TPO) is the major regulator of platelet production in vivo and is the ligand for the MPL receptor. In an effort to determine the distribution of TPO and MPL in the different hematopoietic cell types and in various types of tissue, we examined the mRNA expression of this ligand-receptor pair in two series of human leukemia-lymphoma cell lines(More)
This paper examines cost effective high availability systems based on standardized CompactPCI backplanes. This bus technology allows a fine-grained structural redundancy by hot-swapping peripheral boards at run-time. To quantitatively evaluate the availability of such a system, several models based on Generalized Stochas-tic Petri Nets have been created(More)
This study determined effects of day of oestrous cycle and early pregnancy on sulfated glycoprotein-1 (SGP-1) expression in ovine endometrium. A 364-bp clone of the ovine SGP-1 mRNA was amplified from reverse transcribed Day-15 cyclic endometrial mRNA using the polymerase chain reaction (PCR) and primers specific for the rat SGP-1 mRNA sequence. Nucleotide(More)
An important change in the socioeconomic environment of industrial firms is the increasing diffusion of Internet technologies in production processes. Applications are on the shop floor, e.g. in networking dislocated assembly lines and in assisting management processes, e.g. in production planning and control. Due to this evolution of direct, IP supported(More)
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