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BACKGROUND The purpose of this study was to determine whether implementation of recent guidelines improves in-hospital mortality from acute ST-elevation myocardial infarction (STEMI) in a metropolitan area. METHODS AND RESULTS We organized a network that consisted of the Viennese Ambulance Systems, which is responsible for diagnosis and triage of patients(More)
OBJECTIVES Because of the known CYP3A4 inhibition by calcium-channel blockers (CCBs), we hypothesized that there might be a drug-drug interaction between clopidogrel and dihydropyridines in patients with coronary artery disease. BACKGROUND Clopidogrel is activated by CYP3A4, which also metabolizes CCBs of the dihydropyridine class. METHODS(More)
BACKGROUND At very early stages of acute myocardial infarction (AMI), highly sensitive biomarkers are still lacking. AIM To evaluate the utility of human heart-type fatty acid-binding protein (h-FABP) for early diagnosis of AMI. DESIGN Prospective diagnostic study. METHODS Consecutive patients presenting to the emergency department with chest pain or(More)
OBJECTIVE To evaluate the clinical utility of individualising dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in an all-comers population, including ST-elevation myocardial infarction (STEMI) patients. SETTING Tertiary care single centre registry. PARTICIPANTS 1008 consecutive PCI patients with stent implantation, without(More)
We present the case of a 51-year-old male patient who received adjuvant chemotherapy consisting of oxaliplatin, bolus and continuous 5-fluorouracil (5-FU) and leucovorin after anterior resection because of locally advanced rectal cancer. Preoperative chemotherapy with capecitabine (an oral 5-FU prodrug) had been well tolerated. Two days after initiation of(More)
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