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Drug release from planar matrix systems has been investigated with special emphasis on the influence of a finite dissolution rate on the drug release profile. A mathematical model of the drug dissolution and release processes was formulated in terms of two coupled nonlinear partial differential equations (PDEs). These were solved numerically by using(More)
A mathematical model of drug release from coated pellets with a granular core has been developed. The model includes a dynamic description of all three main processes contributing to drug release from such a system, i.e. liquid inflow, drug dissolution, and liquid efflux caused by diffusion across the coating. The cumulative fraction of released drug has(More)
The purpose of this review is to provide a comprehensive overview of mathematical procedures that can be used to describe the release of drugs from inert matrix systems. The review focuses on general principles rather than particular applications. The inherent multiscale nature of the drug-release process is pointed out and multiscale modelling is(More)
The aim of this study was to investigate the compression behaviour and tablet-forming ability of spray-dried amorphous two- and three-component composite particles. Particles of lactose alone, two-component particles of lactose and PVP, and three-component particles of lactose, PVP and a small amount of polysorbate 80 were prepared by spray-drying. Two(More)
Drug release from spherical matrix systems has been investigated theoretically, with numerical as well as analytical methods. The model used combines the Noyes-Whitney and diffusion equations, and thus takes the effects of a finite dissolution rate into account. The release profile has been determined numerically, by using well-established FORTRAN routines.(More)
Drug release from matrix systems of cylindrical shape is analyzed in detail by using the finite element method. The model used combines the Noyes-Whitney and diffusion equations, and thus takes the effects of a finite dissolution rate into account. The model is valid for all drug solubilities and dissolution rates, and allows accurate predictions of the(More)
The effect of degree of compression on the evolution of tablet microstructure and bond probability during compression of granular solids has been studied. Microcrystalline cellulose pellets of low (about 11%) and of high (about 32%) porosity were used. Tablets were compacted at 50, 100 and 150 MPa applied pressures and the degree of compression and the(More)
The aim of the present study was to investigate the influence of the size and the porosity of excipient microcrystalline cellulose (MCC) particles on the densification and the deformation during compaction and the consequent effect on the drug release from reservoir pellets. Drug pellets consisting of salicylic acid and microcrystalline cellulose were(More)
This article presents a novel drug release model that combines drug dissolution, diffusion, and immobilization caused by adsorption of the drug to the tablet constituents. Drug dissolution is described by the well-known Noyes-Whitney equation and drug adsorption by a Langmuir-Freundlich adsorption isotherm, and these two processes are included as source and(More)
This work investigates the movement of anions during potentiostatic controlled reduction of novel composite materials consisting of high surface area cellulose substrates, extracted from the Cladophora sp. algae, coated with thin ( approximately 50 nm) layers of the intrinsically conducting polymer (ICP) polypyrrole. The coating was achieved by chemical(More)