Géza Burghardt

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We present the isolation and functional analysis of a transformer2 homologue Mdtra2 in the housefly Musca domestica. Compromising the activity of this gene by injecting dsRNA into embryos causes complete sex reversal of genotypically female individuals into fertile males, revealing an essential function of Mdtra2 in female development of the housefly.(More)
The genetic cascades regulating sex determination of the housefly, Musca domestica, and the fruitfly, Drosophila melanogaster, appear strikingly different. The bifunctional switch gene doublesex, however, is present at the bottom of the regulatory cascades of both species, and so is transformer-2, one of the genetic elements required for the sex-specific(More)
Sex-determining cascades are supposed to have evolved in a retrograde manner from bottom to top. Wilkins’ 1995 hypothesis finds support from our comparative studies in Drosophila melanogaster and Musca domestica, two dipteran species that separated some 120 million years ago. The sex-determining cascades in these flies differ at the level of the primary(More)
Stability testing of derivatives of brenzcatechine [norepinephrine hydrogentartrate (1), epinephrine hydrogentartrate (2), isoprenaline sulfate (3)] was carried out by stress investigation storing them at different temperatures. Substances of different charges which had been stored under normal conditions were analyzed. After a period of induction all three(More)
The article in hand presents first HPLC studies on the distribution behaviour of guanylic and N-phenylguanylic hydrazone derivates. The chromatographic parameters of compounds, which had been separated at NH2-columns by 0.06 mol X 1(-1) Na2HPO4 buffer/methanole (30 : 70), could be identified, and the k'/rates could be utilized for the calculation of the(More)
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