Gérard Pivert

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BACKGROUND & AIMS Cystathionine beta-synthase (CBS) deficiency causes severe hyperhomocysteinemia, which confers diverse clinical manifestations, notably liver disease. To investigate this aspect of hyperhomocysteinemia, we performed a thorough investigation of liver pathology in CBS-deficient mice, a murine model of severe hyperhomocysteinemia. METHODS(More)
Hereditary haemophagocytic lymphohistiocytosis (HLH) is a fatal inflammatory disease and treatments currently may lead to serious side effects. There is a pressing need for effective, less toxic treatments for this disease. Previous reports have suggested that interferon gamma (IFNgamma) has a role in the pathogenesis of HLH. Here, we report that blocking(More)
Langerhans cells (LC) are implicated in the initiation and maintenance of inflammatory periodontal diseases. The purpose of this immunohistological study using morphometric and automated image analysis was to determine the morphological features of CD1a+ LC in healthy and inflammatory gingiva according to their localisation in the upper epithelium or the(More)
Griscelli syndrome type 2 is caused by mutations in the RAB27A gene and is a rare and potentially fatal immune disorder associated with hemophagocytic lymphohistiocytosis (HLH). Animal models could provide assistance for better understanding the mechanisms and finding new treatments. Rab27a-deficient (ashen) mice do not spontaneously develop HLH. When(More)
The HIP/PAP (=human Reg-2) C-type lectin encoding gene is activated in primary liver cancers. In normal liver, the protein is undetectable in normal mature hepatocytes and found only in some ductular cells, representing potential hepatic progenitor cells. The aim of this study was to examine the consequences of human HIP/PAP expression in the liver of(More)
BACKGROUND It has been suggested that beneficial effect of elemental enteral diets in the treatment of inflammatory bowel diseases could be mediated by the suppression of protein dietary antigens. The objective of the present work was to study the effect of enteral diet on gut associated lymphoid tissue and on gastric Lactobacillus flora, in rat. METHODS(More)
BACKGROUND AND AIMS The importance of the hepatocyte ploidisation pattern to the control of cell proliferation and differentiation has been well established. However, there are no data that have characterised hepatocyte ploidy at various stages of chronic liver inflammation and fibrosis in vivo. METHODS We therefore investigated hepatocyte(More)
(1) Institut National de la Santé et de la Recherche M Laboratoire du Développement Normal et Patho Immunitaire, Paris, France. (2) Université Paris Descartes, Faculté de Médecine Descartes, Institut Fédératif de Recherche Neck (IFR94), Paris, France. (3) Assistance Publique-Hôpitaux de Paris, Hôpital Nec Unité d’Immunologie et Hématologie Pédiatrique, Pa(More)
BACKGROUND Gingivitis is an inflammatory phenomenon localized in gingival tissues and histologically characterized by an infiltration of several inflammatory cell populations. The purpose of this study was to characterize, localize, and quantify in situ inflammatory and cytotoxic T lymphocytes using immunolabeled gingival tissue sections in order to specify(More)