Gérard Michel

Brigitte Nelken9
André Baruchel9
Denis Hémon8
Jacqueline Clavel8
9Brigitte Nelken
9André Baruchel
8Denis Hémon
8Jacqueline Clavel
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OBJECTIVES We investigated the role of household exposure to pesticides in the etiology of childhood hematopoietic malignancies. METHODS The national registry-based case-control study ESCALE (Etude sur les cancers de l'enfant) was carried out in France over the period 2003-2004. Population controls were frequency matched with the cases on age and sex.(More)
  • Audrey Bonaventure, Stéphanie Goujon-Bellec, Jérémie Rudant, Laurent Orsi, Guy Leverger, André Baruchel +11 others
  • 2011
This study explored interactions between prenatal exposure to maternal smoking and polymorphisms in metabolic genes in the risk of childhood acute leukemia (AL). The data were generated by the ESCALE study, which included 764 AL cases and 1,681 controls in 2003–2004. The data on maternal smoking during pregnancy were obtained by standardized telephone(More)
We report microbiologic analysis of 786 lymph node biopsy specimens from patients with suspected cat-scratch disease (CSD). The specimens were examined by standard, cell culture, and molecular methods. Infectious agents were found in samples from 391 (49.7%) of 786 patients. The most commonly identified infectious agent was Bartonella henselae (245(More)
  • Alicia Amigou, Jérémie Rudant, Laurent Orsi, Stéphanie Goujon-Bellec, Guy Leverger, André Baruchel +10 others
  • 2012
Fetal folate deficiency may increase the risk of subsequent childhood acute leukemia (AL), since folates are required for DNA methylation, synthesis, and repair, but the literature remains scarce. This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T)(More)
BACKGROUND Traffic is a source of environmental exposures, including benzene, which may be related to childhood leukemia. OBJECTIVES A national registry-based case-control study [ESCALE (Etude Sur les Cancers et les Leucémies de l'Enfant, Study on Environmental and Genetic Risk Factors of Childhood Cancers and Leukemia)] carried out in France was used to(More)
BACKGROUND Clofarabine alone or in combination with cyclophosphamide and etoposide has shown a good efficacy and a tolerable toxicity profile in previous studies of children with relapsed or refractory leukaemia. This report describes a retrospective study of 38 French patients who received clofarabine as a monotherapy or in combination for relapsed or(More)
  • Roula Ajrouche, Jérémie Rudant, Laurent Orsi, Arnaud Petit, André Baruchel, Brigitte Nelken +10 others
  • 2014
To investigate the potential involvement of fertility treatments and other conditions of becoming pregnant (infertility, getting pregnant on birth control, maternal history of fetal loss) and folic acid supplements in the etiology of childhood leukemia (CL). The ESTELLE study included 747 cases of CL [636 cases of acute lymphoblastic leukemia (ALL) and 100(More)
Maintenance chemotherapy is an important part of the treatment of ALL in children. It relies on the long-term oral administration of daily low-dose mercaptopurin and weekly low-dose methotrexate. Although it has been used in the clinic for decades, its mechanisms of action remain unclear. Here, we investigated different angiogenic and immune biomarkers to(More)
  • Jérémie Rudant, Laurent Orsi, Audrey Bonaventure, Stéphanie Goujon-Bellec, André Baruchel, Arnaud Petit +10 others
  • 2015
Genome-wide association studies (GWAS) have identified that frequent polymorphisms in ARID5B and IKZF1, two genes involved in lymphoid differentiation, increase the risk of childhood acute lymphoblastic leukemia (ALL). These findings markedly modified the current field of research on the etiology of ALL. In this new context, the present exploratory study(More)
  • Audrey Bonaventure, Jérémie Rudant, Stéphanie Goujon-Bellec, Laurent Orsi, Guy Leverger, André Baruchel +11 others
  • 2013
This study aimed to analyze the associations between childhood acute leukemia (AL) and maternal caffeinated beverage consumption during pregnancy, and to explore interactions between caffeinated and alcoholic beverage consumption and polymorphisms of enzymes involved in caffeine and ethanol metabolisms. The data were generated by the French ESCALE study,(More)