Gérard Fabre

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Purpose. To determine and compare the relationship between in vivo oral absorption in humans and the apparent permeability coefficients (P app ) obtained in vitro on two human intestinal epithelial(More)
Clopidogrel is a prodrug that needs to be converted to its active metabolite (clopi-H4) in two sequential cytochrome P450 (P450)-dependent steps. In the present study, a dynamic physiologically based(More)