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We describe melphalan pharmacokinetics in 26 patients treated by isolated limb perfusion (ILP). Group A (n = 11) were treated with a bolus of melphalan (1.5 mg kg-1), and in a phase I study the dose was increased to 1.75 mg kg-1. The higher dose was given as a bolus to Group B (n = 9), and by divided dose to Group C (n = 6). Using high performance liquid(More)
In this paper we introduce a novel method to perform topic detection in Twitter based on the recent and novel technique of Joint Complexity. Instead of relying on words as most other existing methods which use bag-of-words or n-gram techniques, Joint Complexity relies on String Complexity which is defined as the cardinality of a set of all distinct factors,(More)
In this paper, we define the general framework to describe the diffusion operators associated to a positive matrix. We define the equations associated to diffusion operators and present some general properties of their state vectors. We show how this can be applied to prove and improve the convergence of a fixed point problem associated to the matrix(More)
This paper describes the first results obtained by implementing a novel approach to rank vertices in a heterogeneous graph, based on the PageRank family of algorithms and applied here to the bipartite graph of papers and authors as a first evaluation of its relevance on real data samples. With this approach to evaluate research activities, the ranking of a(More)
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