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Human MicroRNA miR-532-5p Exhibits Antiviral Activity against West Nile Virus via Suppression of Host Genes SESTD1 and TAB3 Required for Virus Replication
ABSTRACT West Nile virus (WNV) is a mosquito-transmitted flavivirus that naturally circulates between mosquitos and birds but can also infect humans, causing severe neurological disease. The earlyExpand
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Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations
JAK2V617F is the most common mutation in patients with BCR-ABL negative myeloproliferative neoplasms (MPNs). The eradication of JAK2V617F hematopoietic stem cells (HSCs) is critical for achievingExpand
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Efficient Code Generation from the High-level Domain-specific Language Feldspar for DSPs
We present Feldspar (Functional Embedded Language for DSP and Parallelism), an embedded, high-level, domain-specific language for algorithm design and the compilation techniques we developed for generating C code from specifications written in it. Expand
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Functional characterisation of Schistosoma japonicum acetylcholinesterase
BackgroundAcetylcholinesterase (AChE) is an important metabolic enzyme of schistosomes present in the musculature and on the surface of the blood stage where it has been implicated in the modulationExpand
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Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG
Herein we describe production of purified equine IgG obtained from horses immunized with plasmid DNA followed by boosting with Kunjin replicon virus-like particles both encoding a modified EbolaExpand
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Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells but not during normal blood formation. Retroviral overexpression of Cdx2 induces AML in mice, however theExpand
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What Functional Programming Can Do for FreeBSD and Vice Versa
In the last decades, scene of functional programming has changed dramatically as many new compilation and programming techniques were introduced, and then became available. Expand
Feldspar – A Functional Embedded Language for Digital Signal Processing*
Digital Signal Processing (DSP) algorithms are usually designed and described on an abstract level and than transformed to a DSP chip specific C code by expert programmers. The problem is that theExpand
Benefits of implementing a query language in purely functional style
Software maintenance can be significantly facilitated with a source code analyser tool. Such a tool is even more powerful, if it provides a fullfledged query language to express queries over theExpand
Measuring Software Complexity by Types
We present a theoretical basis on how to measure software complexity by types, and define some simpler metrics based on it for demonstration. Expand