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Calixarene-mediated assembly of a small antifungal protein
PAF, a small cationic antifungal protein has been co-crystallized with a series of anionic calixarenes to reveal novel interaction modes. The largest ligand, sulfonato-calix[8]arene, yielded a PAFExpand
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From carbohydrates to drug-like fragments: Rational development of novel α-amylase inhibitors.
Starch catabolism leading to high glucose level in blood is highly problematic in chronic metabolic diseases, such as type II diabetes and obesity. α-Amylase catalyzes the hydrolysis of starch,Expand
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Optimization of desferrioxamine E production by Streptomyces parvulus.
Siderophores are produced by a number of microbes to capture iron with outstandingly high affinity, which property also generates biomedical and industrial interests. Desferrioxamine E (DFO-E)Expand
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Simple ITC method for activity and inhibition studies on human salivary α-amylase
Abstract Isothermal titration calorimetry (ITC) has an increasing significance in enzyme kinetic studies owing to its general applicability and sensitivity. In the present work, we aimed atExpand
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A comparative study of capillary electrophoresis and isothermal titration calorimetry for the determination of binding constant of human serum albumin to monoclonal antibody
This paper focuses on the investigation of the interactions between the anti‐HSA‐mAb and its protein antigen using CZE, ACE, and isothermal titration calorimetry. The CZE revealed the formation ofExpand
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α‐Amylase Modulation: Discovery of Inhibitors Using a Multi‐Pharmacophore Approach for Virtual Screening
Better control of postprandial hyperglycemia can be achieved by delaying the absorption of glucose resulting from carbohydrate digestion. Because α‐amylase initiates the hydrolysis ofExpand
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The use of starch azure for measurement of alpha-amylase activity.
Despite being widely used, there is no standard protocol for α-amylase activity measurement with starch azure substrate. Boiling pre-treatment of starch azure suspension increased the reaction rateExpand
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Mathematical description of pH-stat kinetic traces measured during photochemical quinone decomposition.
Substituted 1,4-benzoquinone (QR) derivatives are photosensitive in aqueous solution and form hydroquinones (QR-H2) and hydroxy-quinones (QR-OH), two weak acids in their photoreaction. For thisExpand
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