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BACKGROUND Upwards of 1200 miRNA loci have hitherto been annotated in the human genome. The specific features defining a miRNA precursor and deciding its recognition and subsequent processing are not yet exhaustively described and miRNA loci can thus not be computationally identified with sufficient confidence. RESULTS We rendered pre-miRNA and(More)
Using a functional inequality, the essential spectrum and eigenvalues are estimated for Laplace-type operators on Riemannian vector bundles. Consequently, explicit upper bounds are obtained for the dimension of the corresponding L 2-harmonic sections. In particular, some known results concerning Gromov's theorem and the L 2-Hodge decomposition are(More)
Type 2 diabetes (T2D) is a complex and polygenic disease yet in need of a complete picture of its development mechanisms. To better understand the mechanisms, we examined gene expression profiles of multi-tissues from outbred mice fed with a high-fat diet (HFD) or regular chow at weeks 1, 9, and 18. To analyze such complex data, we proposed a novel dual(More)
Wei Xu, Pan Zhang, Tian Liu4,∗ and Fuzhou Gong School of Mathematics and Systems Science, Beihang University, Beijing 100191, China Santa Fe Institute, Santa Fe, New Mexico 87501, USA State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China Key Laboratory of High Confidence Software(More)
Piwi-interacting RNA (piRNA) is a class of small non-coding RNAs about 24 to 32 nucleotides long, associated with PIWI proteins, which are involved in germline development, transposon silencing, and epigenetic regulation. Identification of piRNA loci on the genome is very useful for further studies in the biogenesis and function of piRNAs. To accomplish(More)
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