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Severe fever with thrombocytopenia syndrome bunyavirus is a newly discovered bunyavirus with high pathogenicity to human. The transmission model has been largely uncharacterized. Investigation on a cluster of severe fever with thrombocytopenia syndrome cases provided evidence of person-to-person transmission through blood contact to the index patient with(More)
BACKGROUND The incidence of dengue, an infectious disease caused by dengue virus (DENV), has dramatically increased around the world in recent decades and is becoming a severe public health threat. However, there is currently no specific treatment for dengue fever, and licensed vaccine against dengue is not available. Vaccination with virus-like particles(More)
To improve the searching ability and convergence speed of differential evolution (DE), we combined a search operation for enhancing the performance of the original DE. The simplified quadratic interpolation (SQI) is employed to improve the local search ability and the accuracy of the minimum function value, and to reduce greatly the computational overhead(More)
BACKGROUND SFTS virus (SFTSV) is a newly discovered pathogen to cause severe fever with thrombocytopenia syndrome (SFTS) in human. Successful control of SFTSV epidemic requires better understanding of the antigen target in humoral immune responses to the new bunyavirus infection. METHODOLOGY/PRINCIPAL FINDINGS We have generated a combinatorial Fab(More)
Enterovirus 71 (EV71) is the etiologic agent of hand-foot-and-mouth disease (HFMD) in the Asia-Pacific region, Many strategies have been applied to develop EV71 vaccines but no vaccines are currently available. Mucosal immunization of the VP1, a major immunogenic capsid protein of EV71, may be an alternative way to prevent EV71 infection. In this study,(More)
—A compact reconfigurable four-feeding microstrip antenna with polarization diversity is presented in this paper. With four triangle-shaped elements as the radiation patch, the proposed antenna can achieve good impedance match for linear polarization (LP), left-hand circular polarization (LHCP) and right-hand circular polarization (RHCP). A four-way power(More)
—A low-profile wideband circularly polarized aperture stacked patch (ASP) antenna without air dielectric layers is presented. The new circular ASP antenna, which is fed by two orthogonal dual-offset lines through an asymmetric crossed slot, delivers a wide bandwidth of 80% for the 10-dB return loss and similar input impedance characteristics for the two(More)
Increasing evidences suggest that the type I interferon α (IFNα) plays a critical role in the etiopathogenesis of systemic lupus erythematosus (SLE), which makes it a promising therapeutic target for the treatment of the disease. By screening a large size non-immune human antibody library, we have developed a human single-chain antibody (ScFv) AIFNα1bScFv01(More)