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Uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists with fast off-rate (UFO) may represent promising drug candidates for various neurodegenerative disorders. In this study, we report that… (More)
Previous studies indicate that memantine, a low-affinity N-methyl-D-aspartate receptor antagonist, exerted acute protective effects against amyloid-β protein-induced neurotoxicity. In the present… (More)
Soluble amyloid-β protein (Aβ) oligomers have been recognized to be early and key intermediates in Alzheimer’s disease-related synaptic dysfunction. In this study, using in vitro electrophysiology,… (More)