Fumiya Ohmasa

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PURPOSE As hypertension (HT) is one of the risk factors for lower urinary tract symptoms, we investigated the effect of an angiotensin II type I receptor blocker, olmesartan, on bladder dysfunction in the spontaneously hypertensive rat (SHR). MATERIALS AND METHODS Twelve-week-old male SHRs were administered perorally with olmesartan (0, 1, or 3 mg/kg/day)(More)
PURPOSE As increasing evidence suggest that α(1)-blockers prevent benign prostatic hyperplasia related overactive bladder and nocturia in the human, we investigated the effects of silodosin and naftopidil on hypertension-related bladder dysfunction in the spontaneously hypertensive rat (SHR) model. MATERIALS AND METHODS Twelve-week-old male SHRs received(More)
AIMS There is increasing evidence that ischemia is one of the main etiology in overactive bladder (OAB), and that nicorandil prevents OAB. We investigated the effect of nicorandil on hypertension-related bladder dysfunction in spontaneously hypertensive rats (SHRs). METHODS Twelve-week-old SHRs received six-weeks treatment with nicorandil (0, 3, or 10(More)
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