Fumitaka Kumagai

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Intraventricular administration to mice porcine calcitonin (10 U/kg) as well as of morphine (3 microgram/kg) elevated the threshold pressure of stimuli applied to the base of the tail as assessed by squeaking, struggling or biting, all of which were regarded as manifestations of pain sensation in the animals. Pretreatment with an opiate antagonist,(More)
INTRODUCTION Diffusion tensor imaging (DTI) reveals white matter pathology in patients with multiple sclerosis (MS). A recent non-Gaussian diffusion imaging technique, q-space imaging (QSI), may provide several advantages over conventional MRI techniques in regard to in vivo evaluation of the disease process in patients with MS. The purpose of this study is(More)
Diffusional kurtosis imaging (DKI) is a new technique based on non-Gaussian water diffusion analysis. However, the original DKI protocol (six b values and 30 motion-probing gradient (MPG) directions) requires more than 10 min of scanning time, which is too long for daily clinical use. We aimed to find suitable b value, MPG direction, and diffusion time(More)
The incidence of the perforated ulcer was 1.5% out of the total mumber of 2.935 cases of the operated gastr ic and duodenal ulcers dur ing the same period. Fourty cases out of 44 perforated ulcers were t rea ted with the gastrectomy, wholly in Bil lroth I. One death was resul ted and the operative morta l i ty rate was 2.5%. In a gereral tendency, the(More)
Since it is generally felt that the diagnosis of chronic gastritis made by gastro-camera is some what limitted, we gastrofiberscopically obtained a piece of mucous membrane of the stomach which was diagnosed by gastro-camera as having chronic gastritis, not associated with stomach tumor, ulcer and polyp, and analysed its histological features. Further it is(More)
Viable Hepatocytes were isolated from adult canine liver by in situ collagenase perfusion, and cultured on collagen coated borosilicate glass plates (100 X 200mm) at confluent cell density. The medium of hepatocytes in the primary culture was L-15 supplemented with aprotinin 5000U/L, proline 30mg/L, insulin 10(-8)M, dexamethasone 10(-8)M, glucagon 10(-8)M,(More)
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