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We evaluated the efficacy and safety of lamotrigine (300 and 500 mg/day) as add-on therapy in a multicenter, randomized, double-blind, parallel-group, placebo-controlled study of 216 patients with refractory partial seizures. During 6 months of treatment, median seizure frequency decreased by 8% with placebo, 20% with 300 mg lamotrigine, and 36% with 500 mg(More)
A series of observations were made on a normal subject, a subject with a non-metallic prosthesis and one with unilateral facial paralysis in order to demonstrate the role of the eyelid in the production of the electrical potential seen during blinking. The findings support the hypothesis that moving the eyelid over the positively charged cornea of an intact(More)
BACKGROUND Acute repetitive seizures are readily recognizable episodes involving increased seizure frequency. Urgent treatment is often required. Rectal diazepam gel is a promising therapy. METHODS We conducted a randomized, double-blind, parallel-group, placebo-controlled study of home-based treatment for acute repetitive seizures. Patients were randomly(More)
Synesthesia is experienced when sensory stimulation of one sensory modality elicits an involuntary sensation in another sensory modality. Auditory-visual synesthesia occurs when auditory stimuli elicit visual sensations. It has developmental, induced and acquired varieties. The acquired variety has been reported in association with deafferentation of the(More)
  • F Matsuo
  • 1984
3 patients suffered from partial epileptic seizures beginning in truncal muscles on one side. A gross anatomical lesion was demonstrated in the contralateral parietal area in 2. In the third patient, both interictal and ictal EEG features were consistent with an epileptogenic lesion in the similar location. Several factors seem to contribute to the rarity(More)
Focal positive spikes and sharp waves in clinical EEG are uncommon (about 1.3 per 1,000 EEGs in this series) and encountered chiefly in early life. All of out seven patients suffered from a convulsive disorder. These discharges must be differentiated from 14 and 6 c/sec positive bursts. Atifactual electrical transients with apparent focal positivity must(More)
An atypical form of herpes simplex encephalitis produced by HSV-1 documented in the present article demonstrates that (1) prominent EEG abnormality may correlate with subtle increase in signal intensity on MRI; (2) the disease may start with prominent involvement of the cingulate gyri; and (3) viral infection of the brainstem may cause early onset of severe(More)
We postulate that palatal myoclonus after infarction of the brainstem or cerebellum, or both, is the manifestation of denervation supersensitivity secondary to lesions involving the dentatorubroolivary system. Two cases of our own and 31 from the English and French literature were analyzed in order to determine the delay between the occurrence of presumed(More)
Myophosphorylase deficiency (McArdle's disease) may present with episodic renal failure following exertion. We present a case of adult-onset myophosphorylase deficiency in which recurrent bouts of renal failure could not be associated with any exertional events until a tonic seizure was witnessed after the fourth episode of renal failure. In the absence of(More)