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  • K. Nakamura, S. Akagi, +15 authors H. Ito
  • Medicine
  • International journal of cardiology
  • 2012 (First Publication: 23 August 2012)
  • BACKGROUND Remodeling of the pulmonary artery by an inappropriate increase of pulmonary artery smooth muscle cells (PASMCs) is problematic in the treatment of idiopathic pulmonary arterialExpand
  • Hiroyuki Otani, Fumio Otsuka, +6 authors Hirofumi Makino
  • Medicine, Biology
  • American journal of physiology. Renal physiology
  • 2007 (First Publication: 1 May 2007)
  • Aldosterone and angiotensin II (ANG II) contribute to the development and progression of renal damage. Here we investigated the effects of bone morphogenetic proteins (BMPs) on renal cellExpand
  • Naoko Tsukamoto, Fumio Otsuka, +9 authors Hirofumi Makino
  • Biology, Medicine
  • Endocrinology
  • 2010 (First Publication: 1 March 2010)
  • The mechanism by which somatostatin analogs suppress ACTH production by corticotropinomas has yet to be fully elucidated. We here studied the effects of somatostatin analogs on ACTH secretion usingExpand
  • Yoshinori Matsumoto, Fumio Otsuka, Mariko Takano, Tomoyuki Mukai, Hirofumi Makino
  • Medicine, Biology
  • Molecular and Cellular Endocrinology
  • 2010 (First Publication: 30 August 2010)
  • Imbalanced functions between osteoclasts and osteoblasts are involved in inflammatory bone damage. The clinical effectiveness of blocking TNF-alpha in treatment of active rheumatoid arthritisExpand
  • Yoshinori Matsumoto, Fumio Otsuka, Jun Hino, Tomoko Miyoshi, Kenji Kangawa
  • Biology, Chemistry, Medicine
  • Molecular and Cellular Endocrinology
  • 2012 (First Publication: 5 March 2012)
  • Despite the involvement of BMP-3b (also called GDF-10) in osteogenesis, embryogenesis and adipogenesis, the functional receptors and intracellular signaling of BMP-3b have yet to be elucidated. InExpand
  • T. Ikeda, K. Nakamura, +12 authors H. Ito
  • Medicine
  • Journal of cardiovascular pharmacology
  • 2010 (First Publication: 1 January 2010)
  • Idiopathic pulmonary arterial hypertension (IPAH) is a progressive disease characterized by inappropriate increase of pulmonary artery smooth muscle cells (PASMCs) leading to occlusion of pulmonaryExpand
  • Misuzu Yamashita, Fumio Otsuka, Tomoyuki Mukai, Ryutaro Yamanaka, Hirofumi Makino
  • Medicine, Biology
  • Regulatory Peptides
  • 2010 (First Publication: 8 June 2010)
  • The mevalonate pathway plays a crucial role in bone metabolism. Here we examined roles of simvastatin in osteoclast function and differentiation induced by RANKL and BMP-2 using mouse macrophage-likeExpand