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In 2005, the WHO Working Group considered odontogenic keratocyst (OKC) to be a tumor and recommended the term keratocystic odontogenic tumor (KCOT), separating the lesion from the orthokeratinizing variant, which is now considered an odontogenic cyst. We analyzed the clinicopathological features of KCOTs encountered over a period of 28 years at Meikai(More)
Eight tumors diagnosed as solitary fibrous tumor (SFT) of the oral cavity were studied. Histologic spectrum was entirely comparable with the extrapleural SFT of other sites. One tumor had glomus tumor-like foci. Immunohistochemical results confirmed most of the previous observations, indicating characteristic expression of vimentin, CD34, bcl-2, and CD99.(More)
To test the hypothesis that nucleotide excision repair (NER) plays a protective role in chemical carcinogenesis in internal organs, xeroderma pigmentosum group A gene-deficient (XPA(-/-)) mice, heterozygous (XPA(+/-)) and wild-type (XPA(+/+)) mice were orally administered 0.001% 4-nitroquinoline 1-oxide (4NQO) in their drinking water and compared. After 50(More)
Urban particulate air pollution is associated with an increased incidence of cancers, and especially lung cancer. Organic extracts of airborne particulate matter (APM) cause cancer in mice, and PAHs adsorbed to APM are associated with particle-induced carcinogenesis. PAHs are agonists for AhR and are predominantly responsible for lung cancer through(More)
Peripheral odontogenic tumor (POT) is a rarely encountered lesion. We report 5 cases of POT including adenomatoid odontogenic tumor (AOT), keratocystic odontogenic tumor (KCOT), ameloblastic fibroma (AF), developing odontoma (DO), and calcifying cystic odontogenic tumor (CCOT), and also provide a review of relevant literature to define the tumor profile.(More)
Xeroderma pigmentosum (XP) is an autosomal recessive hereditary disease featuring defective nucleotide excision repair (NER). XP patients are highly sensitive to sunlight and develop skin cancer at an early age. While the fact that XP patients have a large increase in mortality from skin cancers has been extensively documented, the relation between XP and(More)
An unusual pseudosarcomatous lesion of the oral mucosa is described in a 43-year-old woman. It presented as an aggressive ulcerative mass in the mandibular retromolar gingiva of one month's duration. The lesion was composed of florid myofibroblastic and fibrohistiocytic proliferations with infiltrative margins in an inflammatory background and was(More)
Extrarenal angiomyolipoma is a rare subtype of benign lipomatous tumor composed of adipose tissue, blood vessels, and smooth muscle. We report a 60-year-old woman who developed an angiomyolipomatous tumor of the tongue and discuss the differential diagnosis along with a review of the literature. The term angiomyolipomatous hamartoma is proposed for the(More)
Salivary gland mucinous adenocarcinoma (MAC) is a rarely encountered and poorly understood tumor. We describe two additional cases presenting as a lip lesion of older women. The prognosis was dismal with one death and one patient with recurrent/metastatic disease. Combining these with 19 cases in the literature unveiled that intraoral MAC occurred primarily(More)