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Synthesis of 3-hydroxypyridines using ruthenium-catalyzed ring-closing olefin metathesis.
New synthetic routes to substituted 3-hydroxypyridines 6 are presented. Ring-closing olefin metathesis (RCM)/elimination and RCM/oxidation/deprotection of nitrogen-containing dienes 4 are the keyExpand
  • 45
Ring-closing olefin metathesis for the synthesis of benzene derivatives.
Benzene derivatives were synthesized in excellent yield from 1,4,7-trien-3-ols by tandem ruthenium-catalyzed ring-closing olefin metathesis (RCM)/dehydration. The method was extended to the tandemExpand
  • 17
An Efficient Route to Benzene and Phenol Derivatives via Ring-Closing Olefin Metathesis
Without the formation of inseparable regioisomers, -various substituted phenol derivatives 2 and benzene derivatives 4 were prepared through RCM-tautomerization and RCM-dehydration protocols. A newExpand
  • 16
Recent developments for introducing a hexafluoroisopropanol unit into the Vitamin D side chain
Among numerous studies on synthetic approaches to and the biological activities of vitamin D analogues, we herein focused on falecalcitriol, an analogue of calcitriol (1α,25-dihydroxyvitamin D3), inExpand
  • 4
Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor.
Both 2α- and 2β-hydroxypropyl substituted 14-epi-1α,25-dihydroxy-19-nortachysterols were synthesized to study the human vitamin D receptor (hVDR) binding affinity, binding configurations, andExpand
  • 3
Concise synthesis of 23-hydroxylated vitamin D3 metabolites
Three 23-hydroxylated vitamin D3 derivatives, which are metabolites of 25-hydroxyvitamin D3 produced by CYP24A1 and a related diastereomer, were efficiently synthesized. Each C23 hydroxy unit wasExpand
  • 2
Synthesis and CYP24A1-Dependent Metabolism of 23-Fluorinated Vitamin D3 Analogues
Two novel 23-fluorinated 25-hydroxyvitamin D3 analogues were synthesized using Inhoffen–Lythgoe diol as a precursor of the CD-ring, efficiently. Introduction of the C23 fluoro group was achieved byExpand
  • 1
Synthetic Chemical Probes That Dissect Vitamin D Activities.
Vitamin D3 metabolites are capable of controlling gene expression in mammalian cells through two independent pathways: vitamin D receptor (VDR) and sterol regulatory element-binding protein (SREBP)Expand
  • 1