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Synthesis of 3-hydroxypyridines using ruthenium-catalyzed ring-closing olefin metathesis.
- Kazuhiro Yoshida, Fumihiro Kawagoe, K. Hayashi, Shingo Horiuchi, T. Imamoto, A. Yanagisawa
- Chemistry, Medicine
- Organic letters
- 5 February 2009
New synthetic routes to substituted 3-hydroxypyridines 6 are presented. Ring-closing olefin metathesis (RCM)/elimination and RCM/oxidation/deprotection of nitrogen-containing dienes 4 are the key… Expand
Ring-closing olefin metathesis for the synthesis of benzene derivatives.
- Kazuhiro Yoshida, Fumihiro Kawagoe, N. Iwadate, H. Takahashi, T. Imamoto
- Chemistry, Medicine
- Chemistry, an Asian journal
- 20 October 2006
Benzene derivatives were synthesized in excellent yield from 1,4,7-trien-3-ols by tandem ruthenium-catalyzed ring-closing olefin metathesis (RCM)/dehydration. The method was extended to the tandem… Expand
An Efficient Route to Benzene and Phenol Derivatives via Ring-Closing Olefin Metathesis
- Kazuhiro Yoshida, Shingo Horiuchi, N. Iwadate, Fumihiro Kawagoe, T. Imamoto
- Chemistry
- 1 June 2007
Without the formation of inseparable regioisomers, -various substituted phenol derivatives 2 and benzene derivatives 4 were prepared through RCM-tautomerization and RCM-dehydration protocols. A new… Expand
Recent developments for introducing a hexafluoroisopropanol unit into the Vitamin D side chain
- Fumihiro Kawagoe, T. Sugiyama, M. Uesugi, A. Kittaka
- Chemistry, Medicine
- The Journal of Steroid Biochemistry and Molecular…
- 14 July 2017
Among numerous studies on synthetic approaches to and the biological activities of vitamin D analogues, we herein focused on falecalcitriol, an analogue of calcitriol (1α,25-dihydroxyvitamin D3), in… Expand
Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor.
- D. Sawada, S. Kakuda, A. Takeuchi, Fumihiro Kawagoe, M. Takimoto-Kamimura, A. Kittaka
- Chemistry, Medicine
- Organic & biomolecular chemistry
- 4 April 2018
Both 2α- and 2β-hydroxypropyl substituted 14-epi-1α,25-dihydroxy-19-nortachysterols were synthesized to study the human vitamin D receptor (hVDR) binding affinity, binding configurations, and… Expand
Concise synthesis of 23-hydroxylated vitamin D3 metabolites
- Fumihiro Kawagoe, Toru Sugiyama, K. Yasuda, M. Uesugi, A. Kittaka
- Chemistry, Medicine
- The Journal of Steroid Biochemistry and Molecular…
- 1 February 2019
Three 23-hydroxylated vitamin D3 derivatives, which are metabolites of 25-hydroxyvitamin D3 produced by CYP24A1 and a related diastereomer, were efficiently synthesized. Each C23 hydroxy unit was… Expand
Synthesis and CYP24A1-Dependent Metabolism of 23-Fluorinated Vitamin D3 Analogues
- Fumihiro Kawagoe, K. Yasuda, +4 authors Atsushi Kittaka
- Chemistry, Medicine
- ACS omega
- 28 June 2019
Two novel 23-fluorinated 25-hydroxyvitamin D3 analogues were synthesized using Inhoffen–Lythgoe diol as a precursor of the CD-ring, efficiently. Introduction of the C23 fluoro group was achieved by… Expand
Synthesis of 3‐Hydroxypyridines Using Ruthenium‐Catalyzed Ring‐Closing Olefin Metathesis.
- Kazuhiro Yoshida, Fumihiro Kawagoe, K. Hayashi, Shingo Horiuchi, T. Imamoto, A. Yanagisawa
- Chemistry
- 23 June 2009
Synthetic Chemical Probes That Dissect Vitamin D Activities.
- Akiko Nagata, Yusuke Akagi, +10 authors M. Uesugi
- Chemistry, Medicine
- ACS chemical biology
- 16 October 2019
Vitamin D3 metabolites are capable of controlling gene expression in mammalian cells through two independent pathways: vitamin D receptor (VDR) and sterol regulatory element-binding protein (SREBP)… Expand