Fumiaki Ando

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Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.

Yuki Yoshizaki, Yutaro Mori, +18 authors E Sohara
Biochemical and biophysical research…
2015

Mutations in with-no-lysine kinase (WNK) 1, WNK4, Kelch-like 3 (KLHL3), and Cullin3 result in an inherited hypertensive disease, pseudohypoaldosteronism type II. WNK activates the Na-Cl cotransporter… (More)

KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3.

Emi Sasaki, Koichiro Susa, +13 authors E Sohara
Molecular and cellular biology
2017

Mutations in the with-no-lysine kinase 1 (WNK1), WNK4, kelch-like 3 (KLHL3), and cullin3 (CUL3) genes are known to cause the hereditary disease pseudohypoaldosteronism type II (PHAII). It was… (More)

Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway

Fumiaki Ando, E Sohara, +10 authors Shinichi Uchida
Nature communications
2016

Heritable nephrogenic diabetes insipidus (NDI) is characterized by defective urine concentration mechanisms in the kidney, which are mainly caused by loss-of-function mutations in the vasopressin… (More)

Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus.

Moko Zeniya, Nobuhisa Morimoto, +14 authors Shinichi Uchida
Journal of the American Society of Nephrology…
2015

Recently, the kelch-like protein 3 (KLHL3)-Cullin3 complex was identified as an E3 ubiquitin ligase for with no lysine (WNK) kinases, and the impaired ubiquitination of WNK4 causes… (More)

Synergic Effects of β-Estradiol and Erythromycin on hERG Currents

Fumiaki Ando, Akinori Kuruma, Seiko Kawano
The Journal of Membrane Biology
2011

The incidence rates of long QT syndrome (LQTS) and drug-induced torsades de pointes (TDP) are higher in women than men. Although gonadal steroids are assumed to play an important role in the… (More)

Ser-261 phospho-regulation is involved in pS256 and pS269-mediated aquaporin-2 apical translocation.

Naofumi Yui, Fumiaki Ando, Sei Sasaki, Shinichi Uchida
Biochemical and biophysical research…
2017

Vasopressin catalyzes aquaporin-2 phosphorylation at several serine sites in the C-terminal region. Compared with Ser-256 and Ser-269 phosphorylation, the role of Ser-261 phospho-regulation on… (More)

Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy

Shintaro Mandai, Susumu Furukawa, +16 authors Shinichi Uchida
Scientific reports
2017

Muscle wasting or sarcopenia contributes to morbidity and mortality in patients with cancer, renal failure, or heart failure, and in elderly individuals. Na+-K+-2Cl- cotransporter 1 (NKCC1) is highly… (More)

Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy

Yuki Yoshizaki, Takayasu Mori, +16 authors E Sohara
Scientific Reports
2017

The Kelch-like ECH-associating protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) signaling pathway is the major regulator of cytoprotective… (More)

AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus

Fumiaki Ando, Shuichi Mori, +8 authors Shinichi Uchida
Nature Communications
2018

Congenital nephrogenic diabetes insipidus (NDI) is characterized by the inability of the kidney to concentrate urine. Congenital NDI is mainly caused by loss-of-function mutations in the vasopressin… (More)

Kidney enlargement and multiple liver cyst formation implicate mutations in PKD1/2 in adult sporadic polycystic kidney disease.

Takuya Fujimaru, Takayasu Mori, +14 authors E Sohara
Clinical genetics
2018

Distinguishing autosomal-dominant polycystic kidney disease (ADPKD) from other inherited renal cystic diseases in patients with adult polycystic kidney disease and no family history is critical for… (More)

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