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GABA-mediated transmission is characterized by high variability of synaptic responses. Major contributors to this variability are: presynaptic factors, including release probability and number of release sites; factors that determine synaptic GABA transients in the cleft, including diffusion and the actions of GABA transporters; and postsynaptic factors,(More)
Glutamatergic synapses vary, exhibiting EPSCs of widely different magnitudes and timecourses. The main contributors to this variability are: presynaptic factors, including release probability, quantal content and vesicle composition; factors that modulate the concentration and longevity of glutamate in the cleft, including diffusion and the actions of(More)
A cyclical process of experimentation and theoretical analysis is being used to develop increasingly precise models of the structure and functional mechanisms of membrane proteins. Nucleic acid sequences have been determined for several voltage-gated sodium, calcium and potassium channels from invertebrates and vertebrates and from nerve and muscle tissues.(More)
  • Zhao Alexandrov Y Pn, Pogue Ai, +60 authors Brook Ga Human Neural Cell
  • 2010
Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells.induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation. and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells.(More)
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