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Receptor binding studies of soft anticholinergic agents

• Fenglei Huang, Peter Buchwald, +5 authors Nicholas Bodor
• AAPS PharmSci
• 2001

Receptor binding studies were performed on 24 soft anticholinergic agents and 5 conventional anticholinergic agents using 4 cloned human muscarinic receptor subtypes. The measured pK i values of the… (More)

Design, Pharmacokinetic, and Pharmacodynamic Evaluation of a New Class of Soft Anticholinergics

• Fenglei Huang, Clinton E. Browne, Whei-mei Wu, Attila Juhász, Fubao Ji, Nicholas Bodor
• Pharmaceutical Research
• 2003

Purpose. To design and evaluate a new class of soft anticholinergics with subtype selectivity. Methods. A new class of soft anticholinergics was designed based on the “inactive metabolite” approach.… (More)

Pharmacokinetic and Pharmacodynamic Evaluations of the Zwitterionic Metabolite of a New Series of N-Substituted Soft Anticholinergics

• Whei-mei Wu, Peter Buchwald, Nobuhiro Mori, Fubao Ji, Jiaxiang Wu, Nicholas Bodor
• Pharmaceutical Research
• 2005

This study was conducted to evaluate the zwitterionic common metabolite of a novel series of N-substituted soft analogs of glycopyrrolate both as racemates and as 2R isomers. Activities were assessed… (More)

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