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Safrole Induces Apoptosis in Human Oral Cancer HSC-3 Cells
Phytochemicals have been used as potential chemopreventive or chemotherapeutic agents. However, there are data suggesting a mutagenic effect of some phytochemicals. We hypothesized that safrole would… Expand
The roles of endoplasmic reticulum stress and Ca2+ on rhein-induced apoptosis in A-549 human lung cancer cells.
Although rhein has been shown to induce apoptosis in several cancer cell lines, the mechanism of action of rhein-induced cell cycle arrest and apoptosis at the molecular level is not well known. In… Expand
Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway.
Evidence has accumulated that berberine is able to induce cell cycle arrest and apoptosis in many human cancer cell lines. However, there is no available information on the effects of berberine on… Expand
PEITC inhibits human brain glioblastoma GBM 8401 cell migration and invasion through the inhibition of uPA, Rho A, and Ras with inhibition of MMP-2, -7 and -9 gene expression.
Glioblastoma is the most aggressive primary brain malignancy, and the efficacy of multimodality treatments remains unsatisfactory. Phenethyl isothiocyanate (PEITC), one member of the isothiocyanate… Expand
Tetrandrine induces apoptosis Via caspase‐8, ‐9, and ‐3 and poly (ADP ribose) polymerase dependent pathways and autophagy through beclin‐1/ LC3‐I, II signaling pathways in human oral cancer HSC‐3…
Tetrandrine is a bisbenzylisoquinoline alkaloid that was found in the Radix Stephania tetrandra S Moore. It had been reported to induce cytotoxic effects on many human cancer cells. In this study, we… Expand
Role of human papillomavirus infection in carcinogenesis of oral squamous cell carcinoma with evidences of prognostic association.
- S. Chen, Fu-shun Yu, Y. Chang, Earl Fu, S. Nieh, Yaoh-Shiang Lin
- Journal of oral pathology & medicine : official…
BACKGROUND Betel nut chewing, cigarette smoking and alcohol drinking are thought to be major environmental risk factors responsible for the development of oral squamous cell carcinomas. Oncogenic… Expand
Wogonin inhibits N-acetyltransferase activity and gene expression in human leukemia HL-60 cells.
It is well documented that arylamine carcinogens are N-acetylated by cytosolic N-acetyltransferase (NAT) enzyme. NAT plays an important role in the metabolizing of those arylamine compounds.… Expand
Bufalin Inhibits NCI-H460 Human Lung Cancer Cell Metastasis In Vitro by Inhibiting MAPKs, MMPs, and NF-κB Pathways.
- Shin-Hwar Wu, Yung-Ting Hsiao, +8 authors J. Chung
- Biology, Medicine
- The American journal of Chinese medicine
- 7 October 2015
Bufalin, a component of Chan Su (a traditional Chinese medicine), has been known to have antitumor effects for thousands of years. In this study, we investigated its anti-metastasis effects on… Expand
Safrole suppresses murine myelomonocytic leukemia WEHI‐3 cells in vivo, and stimulates macrophage phagocytosis and natural killer cell cytotoxicity in leukemic mice
Many anticancer drugs are obtained from phytochemicals and natural products. However, some phytochemicals have mutagenic effects. Safrole, a component of Piper betle inflorescence, has been reported… Expand
The role of Ca2+ in (-)-menthol-induced human promyelocytic leukemia HL-60 cell death.
A human promyelocytic leukemia HL-60 cell line was selected to examine the effect of (-)-Menthol on cell death. Based on the results from morphological changes and the percentage of viable cells in… Expand