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BACKGROUND Although numerous prognostic factors have been reported for colorectal cancer liver metastasis (CRLM), few studies have reported intraoperative blood loss (IBL) effects on clinical outcome after CRLM resection. METHODS We retrospectively evaluated the clinical and histopathological characteristics of 139 patients who underwent liver resection(More)
Image in painting is a method to fill in missing region using the information from the remaining area of the image in a visually plausible way. Exemplar-based in painting methods iteratively search the source region and fill the missing region with the best matched patch obtained by SSD criteria. But sometimes matching error would be easily generated(More)
AIM To determine the distal intramural spread (DIS) margin of rectal cancer. METHODS Sixty-one p53-positive specimens of rectal cancer were used. After conventional hematoxylin and eosin (H&E) staining, the DIS margin of rectal cancer in large specimens was examined by immunohistochemistry. The patients were divided into A, B, C, and D groups. After a(More)
BACKGROUND Our aim is to explore the trend of association between the survival rates of colorectal cancer (CRC) and the different clinical characteristics in patients registered from 1960s to 2000s. We hypothesized that the survival rate of CRC increases over time and varies according to anatomic subsites. METHODS Information from a total of 4558 stage(More)
OBJECTIVE To study the molecular risk factors of lymph node metastasis in stage T1 and T2 colorectal cancers by tissue microarray and immunohistochemistry techniques. METHODS Two hundred and three patients with stage T1 and T2 colorectal carcinoma who underwent radical surgery from 1999 to 2010 in our department were included in this study. Their(More)
OBJECTIVE To investigate the effect of activator protein-1 (AP-1) decoy-oligodeoxynucleotides (Decoy-ODNs) on the expression of fibroblast alpha2 type I collagen, so as to explore the gene therapy of pathologic scar. METHODS Decoy-ODNs targeting AP-1 were designed and synthesized. NIH3T3 cells were transfected by cationic liposomes. The distribution of(More)
INTRODUCTION Multimodality therapy, including preoperative chemoradiotherapy (CRT) and total mesorectal excision (TME), has effectively reduced local recurrence rates of rectal cancer over the past decade. However, the benefits and risks of the addition of neoadjuvant CRT to surgery need to be evaluated. This study was to compare the efficacy of TME with(More)
BACKGROUND & OBJECTIVE The optimal distal molecular clearance margin of rectal cancer hasn't been confirmed. This study was designed to explore the molecular margin of distal intramural spread (DIS)in rectal cancer, and its prognostic value, and to further clarify the required distal margin of radical surgery for rectal cancer. METHODS Sixty-one P53(More)
AIM To construct a cycle peptide library composed of 16 random amino acids with yeast two-hybrid system. METHODS Random oligonucleotides encoding 16-mer peptides were designed and synthesized artificially, and then were amplified by PCR. The amplified products were digested with BamH I and EcoR I and cloned into yeast expression plasmid pGADT(7) GH to(More)
OBJECTIVE To compare the effect of 5-fluorouracil (5-FU) portal vein infusion (PVI) for 7 days after radical resection, with intraluminal chemotherapy during operation for eliminating liver metastasis and elevating long-term prognosis in colorectal cancer. METHODS 162 colorectal cancer patients with radical resection were divided into portal vein(More)