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BACKGROUND Horses develop recurrent airway obstruction (RAO) that resembles human bronchial asthma. Differentiated primary equine bronchial epithelial cells (EBEC) in culture that closely mimic the airway cells in vivo would be useful to investigate the contribution of bronchial epithelium in inflammation of airway diseases. However, because isolation and(More)
Although the flavonol quercetin is used as a supplement in commercial dog food, data on quercetin bioavailability in dogs are not available. Thus, we investigated quercetin bioavailability (measured as area under the concentration-time curve) in nine adult beagle dogs at an oral dose of 10 mg/kg body weight (b.w.). The major fraction (>80 %) of flavonols(More)
Bromotrichloromethane (CBrCl(3)) treatment is a model for studies on molecular mechanisms of haloalkane toxicity with some advantages compared with CCl(4) treatment. The formation of 4-hydroxynonenal and similar aldehydic products of lipid peroxidation, which play a role as mediators of inflammatory processes, was clearly demonstrated in rat hepatocytes(More)
The effect of local anesthetics (procaine, nicotinoyl-procaine, tetracaine, and dibucaine) on thymidine uptake and cellular respiration was investigated in hepatocytes from 3- and 24-month-old rats. All local anesthetics inhibited the "high-affinity" as well as the "low-affinity" thymidine transport system in a non-competitive manner immediately upon(More)
1. EXPLANATION Ractopamine hydrochloride, a b-adrenoceptor agonist, is a phenethanolamine salt approved for use as a feed additive. The formulated products, which contain four stereoisomers of the compound, are recommended for use in finishing pigs, at a dose of 5–20 mg/kg of feed to improve feed efficiency and to increase weight gain, or at 10–20 mg/kg of(More)
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