Fritz Lehmann-Grube

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A plaque reduction method for measuring lymphocytic choriomeningitis virus-sensitizing antibody in human serum is described. One volume of virus and one volume of serially diluted human serum were mixed and incubated for 2 h at 37 degrees C. One volume of suitably diluted anti-human immune globulin antiserum was added and incubation continued for 0-5 h.(More)
Injection into mice of chimeric proteins consisting of a portion of either the simian virus 40 large tumor antigen or nonstructural protein 1 of influenza A virus or of the murine tumor suppressor p53 on one hand and T-cell epitopes of lymphocytic choriomeningitis virus on the other resulted in antiviral protective immunity, which was independent of the(More)
Infection of CBA/J mice with low doses of strain WE lymphocytic choriomeningitis (LCM) virus resulted in high cell-mediated and relatively low humoral virus-specific immune phenomena; anamnestic responses were marked. In contrast, infection with high doses of this virus induced no or low degrees of cell-mediated immune phenomena but higher antibody(More)
Virtual environments and online games are becoming a major market force. At the same time, the virtual property contained in these environments is being traded for real money and thus attains a real value. Although the legal issues involved with this virtual property have not yet been decided, they will have to be soon. To protect virtual property, virtual(More)
In mice persistently infected with lymphocytic choriomeningitis virus (LCMV), the parenchymatous organs contain infiltrates of mononuclear cells, the sizes and numbers of which vary between strains and become more numerous and extensive when the animals grow older. Histologically, these were found to possess a tissue-like structure, and by use of(More)
abstraCt Virtual environments and online games are becoming a major market force. At the same time, the virtual property contained in these environments is being traded for real money and thus attains a real value. Although the legal issues involved with this virtual property have not yet been decided, they will have to be soon. It is foreseeable that the(More)
Murine lymphocytic choriomeningitis is a T-cell-mediated pathologic immune phenomenon. The name of this experimental illness was derived from the principal histopathologic alterations of the central nervous system (CNS) of adult mice infected intracerebrally with lymphocytic choriomeningitis virus, i.e., lymphocytic infiltrations of plexus choroidei and(More)
Virtual environments are becoming more and more accepted, and part of the everyday online experience for many users. This offers new potential for both surveillance and data mining. Some of the techniques used are discussed in this paper. However, such activities may in many countries conflict with the legal framework in place, for example with the German(More)
Cooperation and communication, a fundamental part of daily working life, usually take place within rooms. Both the underlying data as well as the conversation, proposals and results may be sensitive. Therefore, protective environments are needed. Since more and more electronic material has to be handled and because of the increase of communication via(More)
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